Arabinoxylan Attenuates Type 2 Diabetes by Improvement of Carbohydrate, Lipid, and Amino Acid Metabolism

Molecular Nutrition & Food Research
Qixing NieShaoping Nie

Abstract

Type 2 diabetes is a complex metabolic and endocrine disorder worldwide, which causes severe health and economic problems. The aim of this study is to investigate the molecular mechanisms by which arabinoxylan from Plantago asiatica L. attenuates type 2 diabetes from the perspective of urine metabolomics. High-fat diet and streptozotocin-induced type 2 diabetic rats are treated with arabinoxylan, then the urine samples are collected for untargeted metabolomics analysis by UPLC-Triple-TOF/MS. Diabetes causes significant increases in the levels of acetone, glucose, 2-oxoglutarate, and leucine, and significant decreases in the concentrations of creatine, histidine, lysine, l-tryptophan, hippurate, l-cysteine, kynurenine, and arabitol as compared with normal rats (p < 0.01). And these 12 metabolites (with VIP cut-off value > 1) can be used as biomarkers in type 2 diabetes. A total of 21 urinary metabolites are significantly improved by arabinoxylan administration in diabetic rats, and these metabolites are mainly involved in TCA cycle, and metabolism of lipid and ketone body, taurine and hypotaurine, tryptophan, and branched chain amino acids. Arabinoxylan administration improves carbohydrate, lipid, and amino acid metabolism in ty...Continue Reading

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Citations

Dec 21, 2018·Critical Reviews in Food Science and Nutrition·Qixing NieShaoping Nie
Mar 23, 2019·Molecular Nutrition & Food Research·Haihong ChenShaoping Nie
Apr 23, 2020·Oxidative Medicine and Cellular Longevity·Yawen ZengJiazhen Yang
May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitri PapukashviliYulin Deng
Feb 13, 2021·Plants·Radu Claudiu FierascuAlina Paunescu
Mar 5, 2021·Life Sciences·Arpita AroraSimona Bungau
May 4, 2021·Critical Reviews in Food Science and Nutrition·Wen ChengHaifeng Qian
Jun 18, 2021·Journal of Agricultural and Food Chemistry·Qixing NieShaoping Nie
Apr 10, 2019·Journal of Agricultural and Food Chemistry·Haihong ChenShaoping Nie

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