PMID: 6432877Sep 1, 1984Paper

Arachidonate 5-lipoxygenase and its new inhibitors

The Journal of Allergy and Clinical Immunology
S YamamotoS Watanabe-Kohno

Abstract

The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14- eicosatetraenoic acid. The activity of both 5-lipoxygenases is calcium dependent and enhanced by adenosine triphosphate and other nucleotides in the presence of calcium ion. Both 5-lipoxygenase activity and leukotriene generation by sensitized guinea pig lung tissue challenged with antigen were suppressed substantially by specific benzoquinone and flavonoid inhibitors. The in vivo significance of the findings will be explored with potent and selective lipoxygenase inhibitors, which are delineated in the 5-lipoxygenase model systems.

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Citations

Jan 1, 1986·Immunologic Research·J S Goodwin
Oct 17, 2007·Applied Microbiology and Biotechnology·Joseph A ChemlerEmmanuel S Tzanakakis
Dec 1, 1987·Journal of Ethnopharmacology·M J Alcaraz, M L Ferrándiz
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W H BettsB Vernon-Roberts
Mar 18, 2003·Journal of Medicinal Food·Saeed HosseiniRonald R. Watson
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·P J Piper
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D BiliciS Altaş
Aug 6, 2008·Journal of Ethnopharmacology·E NyiligiraP A Steenkamp
Apr 25, 2001·The Journal of Parasitology·H L Smith, T V Rajan
Jan 12, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Benjamin H S LauRay A Barreta

Related Concepts

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
Cirsiliol
Metazoa
Arachidonate Lipoxygenases
Basophils
Bioflavonoids
Cavia porcellus
Leukemia, Experimental
Lipoxygenase-2
Lung

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