PMID: 2113900May 1, 1990Paper

Arachidonic acid causes cyclooxygenase-dependent and -independent pulmonary vasodilation

Journal of Applied Physiology
C O FeddersenN F Voelkel

Abstract

In this study we examined the action of arachidonic acid in the isolated rat lung perfused with a cell- and protein-free physiological salt solution. When pulmonary vascular tone was elevated by hypoxia, bolus injection of a large dose of arachidonic acid (75 micrograms) caused transient vasoconstriction followed by vasodilation. When arachidonic acid (100 micrograms) was injected during normoxia and at base-line perfusion pressure (low vascular tone) or when vascular tone was elevated by KCl, arachidonic acid (50 micrograms) caused only vasoconstriction. Doses less than 7.5 micrograms caused vasodilation only when injected during hypoxic vasoconstriction and subsequent blunting of either angiotensin II- or hypoxia-induced pulmonary vasoconstriction. The higher doses of arachidonic acid (7.5 and 75 micrograms), but not the lower doses (7.5-750 ng), caused increases in effluent 6-ketoprostaglandin F1 alpha, thromboxane B2, and prostaglandin E2 and F2 alpha. 6-Ketoprostaglandin F1 alpha was the major cyclooxygenase product. Meclofenamate (10(-5) M) blocked the increased metabolite synthesis over the entire dose range of arachidonic acid tested (7.5 ng-75 micrograms). Because vasodilation immediately after arachidonic acid was cyc...Continue Reading

Citations

May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L Jernigan, Thomas C Resta
May 27, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikki L JerniganThomas C Resta
Nov 10, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brad R S BroughtonThomas C Resta
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T C RestaB R Walker
Jun 28, 2019·Circulation Research·Grazyna KwapiszewskaNorbert F Voelkel
Oct 7, 2004·European Journal of Pharmacology·Pascal GuerardMarc Bardou

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