Arachidonic acid evokes inositol phospholipid hydrolysis in astrocytes

FEBS Letters
S Murphy, G Welk

Abstract

Astrocyte cultures prelabelled with [3H]inositol were exposed to arachidonic acid (AA) in the presence and absence of various agonists. AA alone evoked a dose-dependent increase in the accumulation of inositol phosphates (IP), an effect not secondary to eicosanoid synthesis and release but which was abolished by EGTA. Separation of the IP revealed that AA stimulated increases in inositol tris-, bis- and monophosphates. IP formation evoked by carbachol or norepinephrine was additive with AA, whereas IP formation by platelet activating factor (PAF) or ATP was non-additive with AA. These results suggest that AA released upon stimulation of astrocytes or other cells in the CNS could initiate and/or amplify intercellular signalling.

References

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Citations

Feb 17, 1994·Biochimica Et Biophysica Acta·D L Firsov, R G Parnova
Jan 1, 1991·Neuroscience Research·K Okamoto, M Sekiguchi
Dec 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·H Elgendy, R E Hausman
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P MarinJ Premont
Jun 1, 1990·Journal of Neurochemistry·R MarsaultC Frelin

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