Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002

D E GriswoldN Hanna


The antiinflammatory activity of the structurally novel dual inhibitor of arachidonic acid metabolism, SK&F 86002 was evaluated using arachidonic acid-induced edema and inflammatory cell infiltration. Histological examination demonstrated extensive subcutaneous edema and neutrophil (PMN) accumulation in perivascular and interstitial locations one hour after application of arachidonic acid to the ear. SK&F 86002 and, to a lesser extent, phenidone demonstrated potent inhibition of this inflammatory response following oral and topical administration. Nordihydroguaiaretic acid (NDGA) displayed only topical activity. The selective cyclooxygenase inhibitors ibuprofen and naproxen were either inactive or stimulated ear swelling. Histological evaluation of the lesion in drug-treated animals revealed that SK&F 86002 impaired edema formation and caused a significant reduction in numbers of infiltrating neutrophils. Using arachidonic acid-induced peritoneal exudation, a reduction in the cellular infiltrate was observed after oral treatment with SK&F 86002 or phenidone, but not with naproxen. Taken together, these data illustrate the potent antiinflammatory effects of SK&F 86002 and support the suggestion that 5-lipoxygenase products play ...Continue Reading


Apr 1, 1985·The Journal of Investigative Dermatology·E E OpasJ L Humes
Mar 1, 1986·Inflammation·D E GriswoldS Mong
Jun 1, 1982·The Journal of Pharmacy and Pharmacology·E M DavidsonM J Smith
Oct 2, 1982·Lancet·S D BrainM W Greaves
Nov 20, 1982·Lancet·S A RaeM J Smith
Jan 1, 1981·General Pharmacology·M J Smith
Apr 15, 1983·Biochemical Pharmacology·P M SimmonsS Moncada
Nov 1, 1983·British Journal of Pharmacology·R D CampM J Walport
Dec 1, 1983·Annals of the Rheumatic Diseases·E M DavidsonM J Smith
Jul 1, 1983·British Medical Bulletin·G A Higgs, J R Vane
Apr 1, 1984·The Journal of Investigative Dermatology·J M YoungL M De Young
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·G A Higgs

❮ Previous
Next ❯


Jan 1, 1988·International Journal of Immunopharmacology·J C LeeN Hanna
Feb 1, 1993·International Journal of Immunopharmacology·U PrabhakarA Truneh
Aug 26, 2014·Journal of Ethnopharmacology·Guillermo Schmeda-HirschmannGabriela E Feresin
Dec 1, 1990·Journal of Pharmacological Methods·L M HillegassC Albrightson-Winslow
Jan 1, 1990·Immunopharmacology and Immunotoxicology·B E Barton, L C James
Jul 30, 2010·Journal of Ethnopharmacology·Felipe S FerreiraRômulo R N Alves
Dec 1, 1988·Pharmacological Research Communications·A TubaroR Della Loggia
Jun 5, 2015·Chemical & Pharmaceutical Bulletin·Jee Hee SuhYoung Sik Cho
Jul 10, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Adil I Khan, Paul Kubes
Apr 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E R Burchardt, R Müller-Peddinghaus
Nov 1, 1988·Arthritis and Rheumatism·D E GriswoldN Hanna
Dec 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Israel J M SantosWaltécio O Almeida
Jan 1, 1990·Archives of Oral Biology·B Baroukh, J S Saffar
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C CaraP Kubes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here