Arachidonic acid inhibits 3H-glutamate uptake with different potencies in rodent central nervous system regions expressing different transporter subtypes

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
C Manzoni, T Mennini

Abstract

High-affinity glutamate reuptake in neurons and glial cells, a mechanism involved in the maintenance of physiological excitatory amino acid neurotransmission, can be inhibited by arachidonic acid (AA). We studied the effect of different doses (from 10 to 500 microM) of AA on L-[3H]glutamate uptake in synaptosomes from rat cortex, rat cerebellum and mouse spinal cord. We found that AA inhibition was dose-dependent, but the IC50 in the cortex differed significantly from those in the cerebellum and spinal cord (170+/-7.9 microM vs 42.5+/-5.4 microM and 34.7+/-2.2 microM respectively). We therefore suggest that arachidonic acid modulates uptake differently in relation to the regional expression of the glutamate transporter subtypes.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T StorckW Stoffel
Nov 1, 1990·Trends in Pharmacological Sciences·D Nicholls, D Attwell
Apr 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E WesterbergT Wieloch
May 1, 1982·Journal of Neurochemistry·D E RhoadsE Raghupathy
Mar 24, 1995·The Journal of Biological Chemistry·N ZerangueM P Kavanaugh
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Sep 1, 1993·Neuron·D AttwellM Szatkowski

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Citations

Oct 16, 2009·Molecular Interventions·Christopher B Divito, Susan G Amara
Nov 27, 2007·European Journal of Pharmacology·Elena FumagalliTiziana Mennini
Mar 29, 2000·The Journal of Nutrition·S Garattini
Apr 28, 2021·Neurochemical Research·Niels Christian DanboltYun Zhou
May 23, 2001·Progress in Neurobiology·N C Danbolt
Dec 10, 2002·Neurochemistry International·Paul DesjardinsRoger F Butterworth
Dec 17, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Oct 25, 2003·European Journal of Pharmacology·Nianhang ChenMaarten E A Reith

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