PMID: 2504440Aug 7, 1989Paper

Arachidonic acid metabolism in cultured astrocytes from rat embryo and in C6 glioma cells

Brain Research
Y IshizakiS Murota

Abstract

Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells, which are considered to be of astroglial origin, arachidonic acid was mainly metabolized through the cyclooxygenase pathway and the major metabolites formed were prostaglandin (PG)E2, PGF2 alpha and thromboxane B2.

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Citations

Apr 14, 1994·Biochimica Et Biophysica Acta·C N Serhan
Aug 1, 1995·Progress in Neurobiology·H Katsuki, S Okuda
Aug 1, 1995·Progress in Neurobiology·L F AgnatiK Fuxe
Apr 15, 1991·Neuroscience Letters·Y IshizakiS Murota
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N YuP J Magistretti
Dec 1, 1995·Neurochemical Research·F StaubA Baethmann
Apr 25, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Ivo W Tremont-Lukats, Mark R Gilbert
Dec 1, 1993·The American Journal of Physiology·P S Jackson, K Strange
Jul 1, 1995·The American Journal of Physiology·R Sánchez-OleaH Pasantes-Morales

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