Arachidonic acid transformation is not stimulated in delayed pressure urticaria

The British Journal of Dermatology
F LawlorM Greaves

Abstract

Little is known about the molecular mechanisms or inflammatory mediators involved in delayed pressure urticaria (DPU). Pressure sufficient to provoke lesions was applied to the back of six patients with DPU. The levels of products of arachidonic acid transformation in skin exudate from the pressure challenged skin were estimated immediately after pressure was removed and 6 h later when lesions were present. These were compared to levels estimated in a similar way from unchallenged skin in these patients. Levels of leukotriene C4/D4/E4, prostaglandin E2, 12-hydroxyeicosatetraenoic acid and leukotriene B4 were not raised in lesional skin. Our results suggest that arachidonic acid metabolism is not stimulated in DPU.

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Citations

May 1, 1993·The British Journal of Dermatology·F LawlorM W Greaves
Nov 23, 2013·Immunology and Allergy Clinics of North America·Michihiro HideTakaaki Hiragun
May 4, 2004·Immunology and Allergy Clinics of North America·Frances Lawlor, Anne Kobza Black
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·M Greaves
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W Greaves
Jan 1, 1991·The British Journal of Dermatology·A Kobza BlackR J Pye
Feb 13, 2018·Immunological Reviews·Martin K ChurchMarcus Maurer

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