Arachidonic and docosahexanoic acid content of bovine brain myelin: implications for the pathogenesis of multiple sclerosis

Neurochemical Research
K A Ansari, D W Shoeman

Abstract

Lipids were extracted from bovine brain myelin using a mixture of hexane and isopropanol (3:2). Myelin lipids were resolved, using Sep Pak chromatography, into four fractions: Fraction 1 contained neutral lipids, fraction 2, free fatty acids, fraction 3, ethanolamine phospholipids and fraction 4, choline phospholipids. Doscosahexanoic (DHA) and arachidonic (AA) acids in these fractions were measured by RPHPLC. Fraction 2 was analyzed directly, the other three fractions were subjected to alkaline hydrolysis before analysis for DHA and AA. DHA and AA were not found in fraction 1. Both DHA and AA were found in fractions 2 and 3. Only AA was consistently found in fraction 4. These results were confirmed by GC.

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Citations

Feb 18, 2011·The Journal of Biological Chemistry·Marcus O W GrimmTobias Hartmann
Aug 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J Kamphuis, R J Wurtman
Jan 22, 2010·Women's Health·Jennifer G RobinsonWilliam Harris
Apr 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J Fretland
Mar 15, 2013·International Journal of Molecular Sciences·Marcus O W GrimmTobias Hartmann
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C DebruyneJ L De Reuck

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