Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting

PloS One
Przemysław CiepielaRafał Kurzawa

Abstract

To evaluate human oocyte ability to undergo fertilization and subsequent preimplantation embryonic development in relation to a wide panel of follicular fluid (FF) arachidonic acid derivatives (AAD) and linoleic acid derivatives (LAD) of prospectively selected patients undergoing intracytoplasmic sperm injection (ICSI). Study was designed as a two center (a university clinic and a private clinic) prospective study. 54 women of 181 consecutive couples undergoing ICSI were prospectively found to be eligible for analysis. 'One follicle - one retrieved oocyte - one resulting embryo' approach was used. Each individual follicle was aspirated independently and matched to an oocyte growing in this particular follicular milieu. FF samples were assessed for AAD and LAD by high-performance liquid chromatography; additionally, activity of secretory phospholipase A (sPLA2) was determined by enzyme-linked immunosorbent assay. Increased activity of sPLA2 and significantly higher AAD and LAD levels were found in FF of oocytes that did not show two pronuclei or underwent degeneration after ICSI in comparison to oocytes with the appearance of two pronuclei. Receiver operating characteristics curve analysis identified acids with the highest sensi...Continue Reading

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Citations

Mar 17, 2018·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisMarialena Trivella
Mar 31, 2018·Journal of Cellular and Molecular Medicine·Rong HuangTao Tao
May 24, 2017·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisDennis Vaidakis
May 19, 2018·Journal of Assisted Reproduction and Genetics·Przemysław CiepielaRafał Kurzawa
Dec 14, 2018·Journal of Assisted Reproduction and Genetics·José-Ignacio Ruiz-SanzMaría-Begoña Ruiz-Larrea
Nov 15, 2017·Human Reproduction·Y-H ChiuUNKNOWN EARTH Study Team
Jun 30, 2019·Animals : an Open Access Journal From MDPI·Nina ZhangZhongliang Jiang
Jul 18, 2018·Journal of Assisted Reproduction and Genetics·Fernanda Bertuccez CordeiroEdson Guimaraes Lo Turco
Oct 12, 2019·Free Radical Biology & Medicine·Irantzu Pérez-RuizJosé-Ignacio Ruiz-Sanz

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Statistica
Agilent ChemStation

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