Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp

Journal of Natural Products
Zeinab KhalilRobert J Capon

Abstract

Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 μM) and a panel of human cancer cell lines (IC50 > 7.5 μM). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin.

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Citations

Aug 5, 2016·Journal of Natural Products·Li-Jian DingHou-Wen Lin
Feb 24, 2017·Journal of Natural Products·Guillermo TarazonaCarmen Cuevas
Jul 22, 2020·Archives of Pharmacal Research·Cong WangShugeng Cao
Mar 16, 2017·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 23, 2021·Current Microbiology·Lei ChenGuangyu Wang
Dec 16, 2020·The Journal of Organic Chemistry·Osama G MohamedRobert J Capon

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