Arbaprostil's [15(R)-15-methyl PGE2] effects on intrauterine pressure in the nonpregnant and pregnant human female--a report of four clinical trials

Prostaglandins, Leukotrienes, and Essential Fatty Acids
A R EulerM Kitt


Four clinical trials evaluating arbaprostil's effects on the human uterus are reported. The initial two trials measured intrauterine pressures in nonpregnant and pregnant human females following arbaprostil doses of 10, 25, and/or 50 mcg. No statistical differences were found at any dosage level in either study for average uterine resting pressures, average peak pressures, the number of contractions or Montevideo units. Subsequently, two trials determined the abortifacient potential of arbaprostil in pregnant women during the first trimester. The first utilized total daily doses of 400 and 800 mcgs. while the second used total daily doses of 1200 and 1600 mcgs. Vaginal spotting was noted in one woman receiving 400 mcgs, three receiving 1200 mcgs. and in two receiving 1600 mcgs. One episode of moderate bleeding was seen in the latter study. Based on these studies, arbaprostil exhibits little potential for inducing abortifacient activity at these dosages in these patient populations.


Jan 1, 1979·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·M BygdemanV Lundström
Sep 1, 1975·Prostaglandins·P Mocsary, A I Csapo
Jan 1, 1983·Acta Obstetricia Et Gynecologica Scandinavica. Supplement·M BygdemanV Lundström

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