Arbutamine vs. exercise stress testing in patients with coronary artery disease: evaluation by echocardiography and electrocardiography

International Journal of Cardiology
L E GinztonW F Armstrong

Abstract

Arbutamine is a new beta-adrenergic agonist with potent chronotropic and inotropic properties developed to pharmacologically induce stress. A prospective trial was conducted in five centers with a total enrolment of 45 patients with angiographically documented coronary artery disease. The primary purpose of the trial was to compare the efficacy of arbutamine with symptom-limited exercise in provoking clinical (angina), electrocardiographic (> or = 0.1 mV ST depression) and echocardiographic (induced wall motion abnormality) evidence of transient stress-induced ischemia. The secondary purpose was to assess the safety of arbutamine in patients with coronary artery disease. Ischemia was induced at a lower heart rate, systolic blood pressure and pressure-rate product during arbutamine infusion than during exercise. Using angina and/or electrocardiographic evidence of ischemia, arbutamine was more sensitive than exercise in detecting myocardial ischemia (77 vs. 58%, P = 0.021). Using echocardiography, the sensitivity for inducing wall motion abnormalities was 88% with arbutamine and 79% with exercise (P = not significant). Echocardiography in combination with angina and/or electrocardiographic evidence increased the sensitivity to 9...Continue Reading

References

May 1, 1992·Journal of the American College of Cardiology·P K MazeikaC M Oakley
Jul 1, 1990·American Heart Journal·S G SawadaW F Armstrong
Nov 1, 1980·The American Journal of Cardiology·J T PhilbrickA R Feinstein
Feb 1, 1994·Journal of the American College of Cardiology·H K Hammond, M D McKirnan
Apr 1, 1993·Journal of the American College of Cardiology·P A MarcovitzW F Armstrong

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Citations

Dec 20, 2003·Progress in Cardiovascular Diseases·Rita F Redberg, Leslee J Shaw

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