Arc1p: anchoring, routing, coordinating

FEBS Letters
Mathieu FrechinBruno Senger

Abstract

Accurate synthesis of aminoacyl-tRNAs (aa-tRNA) by aminoacyl-tRNA synthetases (aaRS) is an absolute requirement for errorless decoding of the genetic code and is studied since more than four decades. In all three kingdoms of life aaRSs are capable of assembling into multi-enzymatic complexes that are held together by auxiliary non-enzymatic factors, but the role of such macromolecular assemblies is still poorly understood. In the yeast Saccharomyces cerevisiae, Arc1p holds cytosolic methionyl-tRNA synthetase ((c)MRS) and glutamyl-tRNA synthetase ((c)ERS) together and plays an important role in fine tuning several cellular processes like aminoacylation, translation and carbon source adaptation.

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Citations

Nov 26, 2010·The Journal of Biological Chemistry·Vlatka Godinic-MikulcicIvana Weygand-Durasevic
Jul 24, 2012·Nucleic Acids Research·Chih-Chi LiaoChien-Chia Wang
Oct 19, 2010·Protein Science : a Publication of the Protein Society·Svitlana HavrylenkoMarc Mirande
Jun 21, 2011·The Journal of Biological Chemistry·Svitlana HavrylenkoMarc Mirande

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