Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice

European Journal of Immunology
Joseph TintelnotManuel A Friese

Abstract

The key function of migratory dendritic cells (migDCs) is to take up antigens in peripheral tissues and migrate to draining lymph nodes (dLN) to initiate immune responses. Recently, we discovered that in the mouse immune system activity-regulated cytoskeleton associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) is exclusively expressed by migDCs and is a central driver of fast inflammatory migration. However, the frequency of Arc/Arg3.1-expressing cells in different migDC subsets and Langerhans cells (LCs), their phylogenetic origin, transcription factor dependency, and functional role remain unclear. Here, we found that Arc/Arg3.1+ migDCs derived from common DC precursors and radio-resistant LCs. We detected Arc/Arg3.1+ migDCs in varying frequencies within each migDC subset and LCs. Consistently, they showed superiority in inflammatory migration. Arc/Arg3.1 expression was independent of the transcription factors Irf4 or Batf3 in vivo. In intradermal Staphylococcus aureus infection that relies on inflammatory antigen transport, Arc/Arg3.1 deletion reduced T-cell responses. By contrast, Arc/Arg3.1 deficiency did not hamper the immune response to systemic Listeria monocytogenes infection, which does not require antigen tra...Continue Reading

References

Jan 14, 1994·Cell·K A HogquistF R Carbone
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B PulendranC R Maliszewski
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn E FouldsHao Shen
Nov 5, 2002·Nature Immunology·Miriam MeradEdgar G Engleman
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shoichi SuzukiAtsushi Kumatori
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohiko TamuraKeiko Ozato
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roxane TussiwandMarkus G Manz
Dec 17, 2009·The Journal of Experimental Medicine·Florent GinhouxMiriam Merad
Jan 24, 2012·Nature Neuroscience·Sandra SiegertBotond Roska
Apr 24, 2012·The Journal of Clinical Investigation·Mercedes Gomez de AgüeroBertrand Dubois
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Derek C LaceyJohn A Hamilton
Aug 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra BajañaSusan Kovats
Jul 3, 2013·Nature Immunology·Jan HettingerMarkus Feuerer
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Friederike RaczkowskiMagdalena Huber
Sep 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karin SteinbachManuel A Friese
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand
May 20, 2014·Immunity·Alexander Mildner, Steffen Jung
May 24, 2014·Nature Reviews. Immunology·Bernard MalissenSandrine Henri
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Dec 4, 2014·Nature·Elisa Gomez PerdigueroHans-Reimer Rodewald
Dec 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina TebartzEva Medina
Feb 11, 2015·Annual Review of Immunology·Bali Pulendran
Nov 12, 2015·Frontiers in Immunology·Björn E Clausen, Patrizia Stoitzner
Jan 10, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra BajañaSusan Kovats
Mar 22, 2016·Pathogens·Barbara M BrökerVincent Péton

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