Architectural analysis of oral cancer, dysplastic, and normal epithelia

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
G Landini, Ibrahim E Othman

Abstract

We present a novel, automated, and quantitative approach to evaluate local epithelial tissue architecture based on mathematical graph theory. Four hundred forty-one images of three diagnostic classes of oral epithelium (normal, dysplastic, and neoplastic) were analysed. The epithelial compartment was partitioned into exclusive areas associated with each nucleus to approach the theoretical cell extents. The spatial arrangement of cells in neighbourhoods of two sizes was characterised by constructing graph networks based on the cell centroids and recording 29 statistical properties. We analysed 104,627 and 67,590 neighbourhoods of diameters 37.5 and 75 microm, respectively. The discrimination power of the architectural descriptors was evaluated by using discriminant analysis. The best neighbourhood discrimination rate was 75% for normal versus carcinoma. For the pooled data, discrimination into three classes based on largest number of neighbourhoods associated with each class was 100% correct. Case-wise, discrimination rates were 67%, 100%, and 80% correct for normal, premalignant, and malignant. When considering two classes, discrimination rates was 89% (normal) and 100% (malignant) correct, with 71% of premalignant cases assign...Continue Reading

References

Oct 1, 1985·Journal of Oral Pathology·J J PindborgP Holmstrup
Aug 1, 1994·Histopathology·J A Morris
Apr 1, 1994·The Journal of Pathology·S S CrossD W Cotton
Jun 1, 1996·The Journal of Pathology·K A Fleming
Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·J SudbøA Reith
Jun 16, 2001·The Journal of Pathology·F T Bosman
Jul 6, 2001·The Journal of Pathology·S Warnakulasuriya
Feb 18, 2003·Journal of Microscopy·G Landini, I E Othman

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Citations

May 5, 2012·Bioinformatics·Noppadon KhiripetJohn R Jungck
Jan 6, 2010·Micron : the International Research and Review Journal for Microscopy·M Muthu Rama KrishnanAjoy K Ray
Jun 6, 2012·IEEE Transactions on Pattern Analysis and Machine Intelligence·D A RandellA Galton
Aug 11, 2006·Current Opinion in Biotechnology·Rodrigo Fernández-GonzálezCarlos Ortiz-de-Solorzano
Jan 25, 2012·Computational and Mathematical Methods in Medicine·Shengyong ChenJianwei Zhang
Mar 11, 2017·PloS One·Francesca CarellaGabriel Landini
Jan 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Stephan SchwarzGero Brockhoff
Dec 20, 2016·Computers in Biology and Medicine·Joao B FlorindoGabriel Landini

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