Architectural and morphological assessment of rat abdominal wall muscles: comparison for use as a human model.

Journal of Anatomy
Stephen H M BrownRichard L Lieber

Abstract

The abdominal wall is a composite of muscles that are important for the mechanical stability of the spine and pelvis. Tremendous clinical attention is given to these muscles, yet little is known about how they function in isolation or how they interact with one another. Given the morphological, vascular, and innervation complexities associated with these muscles and their proximity to the internal organs, an appropriate animal model is important for understanding their physiological and mechanical significance during function. To determine the extent to which the rat abdominal wall resembles that of human, 10 adult male Sprague-Dawley rats were killed and formalin-fixed for architectural and morphological analyses of the four abdominal wall muscles (rectus abdominis, external oblique, internal oblique, and transversus abdominis). Physiological cross-sectional areas and optimal fascicle lengths demonstrated a pattern that was similar to human abdominal wall muscles. In addition, sarcomere lengths measured in the neutral spine posture were similar to human in their relation to optimal sarcomere length. These data indicate that the force-generating and length change capabilities of these muscles, relative to one another, are simil...Continue Reading

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Citations

Jun 12, 2014·International Urogynecology Journal·Marianna AlperinRichard L Lieber
Mar 30, 2016·The Journal of Surgical Research·Kevin G CornwellWilliam Lineaweaver
Jan 24, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stephen H M BrownRichard L Lieber
Mar 8, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G VesentiniM V C Rudge
Aug 11, 2011·Cells, Tissues, Organs·Eleftherios KellisGeorge Kapetanos
Aug 17, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Chenglei FanCarla Stecco
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·William W LaoFu-Chan Wei
Mar 25, 2021·Anesthesiology·Franco Laghi, Nicola Cacciani

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