PMID: 8584266Nov 10, 1995Paper

Architectural changes of the cortico-spinal system in the dystrophin defective mdx mouse

Neuroscience Letters
Alessandro SbriccoliD Minciacchi

Abstract

The mutant mdx mice which lack the protein dystrophin are an animal model of Duchenne muscular dystrophy. We studied the organization of the cortico-spinal (CS) system in mdx mice using the horseradish peroxidase retrograde tracing technique. Tracer injections were placed in the cervical spinal cord of mutant and control mice. The tangential and radial distribution of CS labeled neurons were similar in mdx and normal mice. Conversely, the absolute number and the cell packing density of labeled CS neurons were considerably lower in mdx than in controls. In mdx, the average size of CS cells was smaller while the perikaryal sizes displayed a normal distribution. In addition, CS neurons of mdx appeared round-shaped compared to the pyramidal cells labeled in control animals. The structural modifications described here should prompt a reconsideration of the involvement of central nervous system in the dystrophin deficient mdx mice.

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Citations

Oct 12, 2010·Brain Structure & Function·Huazheng LiangCharles Watson
Mar 10, 1997·Journal of the Neurological Sciences·P GirlandaG Vita
Jan 8, 1999·Brain Research. Developmental Brain Research·S GianinoX M Xu
Dec 12, 2001·Neuromuscular Disorders : NMD·Caroline RaeStewart Head
Aug 23, 2012·PloS One·Gustavo Ferreira Simões, Alexandre Leite Rodrigues de Oliveira
May 26, 2012·Trends in Neurosciences·Adrian WaiteDerek J Blake
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M GodfraindK Krnjević
Feb 28, 2007·Neuroscience Letters·Magali Luci PintoRita de Cássia Ribeiro da Silva Lapa
Dec 19, 2003·Annals of the New York Academy of Sciences·Diego Minciacchi
Jul 22, 2014·Annals of Neurology·Nathalie DoorenweerdHermien E Kan
Jul 8, 2008·Brain Research·Magali Luci PintoRita de Cássia Ribeiro da Silva Lapa
Jan 22, 2008·Neuromuscular Disorders : NMD·Laura GraciottiGianluca Fulgenzi
Sep 22, 2012·Brain Research·Paulo César GhediniCaden Souccar
Feb 14, 2015·Neuroscience and Biobehavioral Reviews·Ruben G F HendriksenMarlien W Aalbers
Dec 3, 2014·Brain Research Bulletin·Erez James CohenDiego Minciacchi
Oct 30, 2016·Neuromuscular Disorders : NMD·Rubén MirandaCyrille Vaillend
Jun 27, 2009·Neuropathology and Applied Neurobiology·G F Simões, A L R Oliveira
Feb 9, 2002·Brain : a Journal of Neurology·J L AndersonJ W Morley
Dec 15, 2019·Molecular Neurobiology·Michael Naidoo, Karen Anthony

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