Architecture and gating of Hv1 proton channels.

The Journal of Physiology
Francesco TombolaEhud Y Isacoff

Abstract

Voltage-gated proton channels have been described in different cells and organisms since the early '80s, but the first member of the family, Hv1, was cloned only recently. The Hv1 channel was found to contain a voltage-sensing domain (VSD), similar to those of voltage-gated sodium, potassium and calcium channels. All these other channels also contain a pore domain, which forms a central pore at the interface of the four subunits. The pore domain is missing in Hv1. This raised several questions on the location of the proton pore and on the mechanism of gating. Here, we briefly review our effort to understand the structural organization of Hv1 channels and discuss the relationship between the gating of Hv1 and the gating of ion-conducting pores recently discovered in the VSDs of mutant voltage-gated potassium and sodium channels.

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Citations

Mar 10, 2010·Pflügers Archiv : European journal of physiology·Jörg StriessnigAlexandra Koschak
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephan Frings
Nov 17, 2009·The Journal of Physiology·Yoshihiro Kubo, Ehud Y Isacoff
Apr 4, 2015·Neuropharmacology·Sahil Talwar, Joseph W Lynch
Feb 4, 2014·Antioxidants & Redox Signaling·Tamara SeredeninaKarl-Heinz Krause
Mar 13, 2012·International Journal of Molecular Sciences·Alisher M Kariev, Michael E Green
Jan 13, 2019·International Journal of Molecular Sciences·Francisco BarrosPilar de la Peña
Mar 25, 2018·Pflügers Archiv : European journal of physiology·Pilar de la PeñaFrancisco Barros
Dec 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eleonora GiantiVincenzo Carnevale
Nov 28, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ruiming ZhaoSteve A N Goldstein

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