Architecture control of three-dimensional polymeric scaffolds for soft tissue engineering. I. Establishment and validation of numerical models

Journal of Biomedical Materials Research. Part a
Yang CaoJustin J Cooper-White

Abstract

One of the most important functions of artificial three-dimensional (3D) polymeric scaffolds is to serve as a physical support to provide tissues with an appropriate architecture for in vitro cell culture as well as in vivo tissue regeneration. The production of three-dimensional (3D) polymeric scaffolds with tailored macroporous architecture is thus a crucial step in promoting controlled vascularization and tissue growth within host environments. In this study, 3D poly(lactic-co-glycolic acid) (PLGA) scaffolds were manufactured by a thermally induced phase-separation (TIPS) technique. By controlling the quenching strategy, 3D interconnected PLGA scaffolds with tunable pore size and alignment were obtained and characterized with the use of scanning electron microscopy (SEM). A series of numerical heat-transfer models were established in an effort to describe the cooling process within the PLGA freezing regime. Among them, a two-dimensional (2D) solidification model has proved to be the most successful in describing the quenching of the polymer solution and has the potential to be used to infer the various 3D macroporous architectures created from different quenching conditions.

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Citations

Jun 14, 2006·Journal of Biomaterials Science. Polymer Edition·Yang CaoJustin J Cooper-White
Jan 31, 2007·Journal of Biomaterials Science. Polymer Edition·George V FranksDavid Phelan
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·K M PawelecR E Cameron
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Fernanda V BertiLuismar M Porto
Jul 9, 2008·Disability and Rehabilitation·Pankaj Sharma, Nicola Maffulli
Jun 28, 2015·Journal of Biomechanics·Michelle T SunJohn J Costi
Oct 18, 2016·Ophthalmic Plastic and Reconstructive Surgery·Michelle T SunDinesh Selva
Dec 12, 2019·Tissue Engineering and Regenerative Medicine·Michelle T SunDinesh Selva

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