Architecture, Function, and Substrates of the Type II Secretion System

EcoSal Plus
Konstantin V Korotkov, Maria Sandkvist

Abstract

The type II secretion system (T2SS) delivers toxins and a range of hydrolytic enzymes, including proteases, lipases, and carbohydrate-active enzymes, to the cell surface or extracellular space of Gram-negative bacteria. Its contribution to survival of both extracellular and intracellular pathogens as well as environmental species of proteobacteria is evident. This dynamic, multicomponent machinery spans the entire cell envelope and consists of a cytoplasmic ATPase, several inner membrane proteins, a periplasmic pseudopilus, and a secretin pore embedded in the outer membrane. Despite the trans-envelope configuration of the T2S nanomachine, proteins to be secreted engage with the system first once they enter the periplasmic compartment via the Sec or TAT export system. Thus, the T2SS is specifically dedicated to their outer membrane translocation. The many sequence and structural similarities between the T2SS and type IV pili suggest a common origin and argue for a pilus-mediated mechanism of secretion. This minireview describes the structures, functions, and interactions of the individual T2SS components and the general architecture of the assembled T2SS machinery and briefly summarizes the transport and function of a growing li...Continue Reading

References

Sep 27, 2019·Molecular Microbiology·Vladimir Pelicic
Aug 14, 2019·Infection and Immunity·Richard C WhiteNicholas P Cianciotto
Aug 14, 2019·The Protein Journal·Peter J Christie
Jun 24, 2020·International Journal of Molecular Sciences·Anna KloskaPaweł Olszewski
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