PMID: 8950014Nov 1, 1996Paper

Architecture of a gain controller in the pursuit system

Behavioural Brain Research
E G Keating, A Pierre

Abstract

A monkey can pursue faster target oscillations if they appear during ongoing smooth pursuit than if they appear while the monkey is fixating a stationary target. Others have proposed a switch in the pursuit circuit to account for this bistable sensitivity to high frequency targets. It is hypothesized that the switch is closed only during pursuit, permitting the retinal motion signal to pass through the circuit at full gain. Losses in pursuit gain caused by certain cortical lesions do mimic the effect of a switch jammed open. To explore this gain adjustment mechanism further, we measured in monkeys the smooth eye movements in response to a high frequency sinusoidal target (called 'humm') presented under a variety of testing conditions. Pursuit gain measured in response to this humm was not merely bistable. Rather, a graded gain modulation of the pursuit system was possible. Furthermore, the gain adjustment had some directional sensitivity to it, enhancing the response to humm along one axis more than the other. In exploring the factors which gated the gain adjustment, it appeared that the movement of the eyes and not the image motion that occurs during pursuit was paramount for enhancing pursuit gain. Gain was not enhanced by sa...Continue Reading

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Citations

Jun 15, 2007·Experimental Brain Research·Jennifer LaddaAndreas Straube
Oct 4, 2008·Cerebral Cortex·Ulrich NudingStefan Glasauer
Dec 17, 2005·Journal of Cognitive Neuroscience·Hiromitsu TabataKenji Kawano
Oct 26, 2010·Vision Research·Shaun Mahaffy, Richard J Krauzlis
Aug 23, 2008·Progress in Brain Research·Ulrich NudingStefan Glasauer
Mar 13, 2003·Experimental Brain Research·Yasushi Kodaka, Kenji Kawano
Mar 5, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Richard J Krauzlis
Feb 6, 2004·Journal of Neurophysiology·Richard J Krauzlis
Sep 8, 2006·Journal of Neurophysiology·Hiromitsu TabataKenji Kawano
Apr 4, 2008·Journal of Neurophysiology·Ulrich NudingStefan Glasauer
Dec 29, 2020·Journal of Neurophysiology·Jonathan D CoutinhoGunnar Blohm

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