Architecture of cannabinoid signaling in mouse retina.

The Journal of Comparative Neurology
Sherry Shu-Jung HuA Straiker

Abstract

Cannabinoid receptors and their ligands constitute an endogenous signaling system that is found throughout the body, including the eye. This system can be activated by Delta(9)-tetrahydrocannabinol, a major drug of abuse. Cannabinoids offer considerable therapeutic potential in modulating ocular immune and inflammatory responses and in regulating intraocular pressure. The location of cannabinoid receptor 1 (CB(1)) in the retina is known, but recently a constellation of proteins has been identified that produce and break down endocannabinoids (eCBs) and modulate CB(1) function. Localization of these proteins is critical to defining specific cannabinoid signaling circuitry in the retina. Here we show the localization of diacylglycerol lipase-alpha and -beta (DGLalpha/beta), implicated in the production of the eCB 2-arachidonoyl glycerol (2-AG); monoacylglycerol lipase (MGL) and alpha/beta-hydrolase domain 6 (ABHD6), both implicated in the breakdown of 2-AG; cannabinoid receptor-interacting protein 1a (CRIP1a), a protein that may modulate CB(1) function; and fatty acid amide hydrolase (FAAH) and N-acylethanolamine-hydrolyzing acid amidase (NAAA), which have been shown to break down the eCB anandamide and related acyl amides. Our m...Continue Reading

References

Jan 1, 1985·Acta Anatomica·D S SchreinerD E Lawson
Jan 1, 1993·Visual Neuroscience·A H MilamA M Dizhoor
Dec 4, 1996·Biochemical and Biophysical Research Communications·M D RandallD A Kendall
Dec 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerM Göthert
Apr 1, 1997·Journal of Neurophysiology·E Hartveit
Nov 22, 1997·European Journal of Pharmacology·M D Randall, D A Kendall
Apr 29, 1998·Trends in Pharmacological Sciences·M D Randall, D A Kendall
Dec 14, 1999·The Journal of Comparative Neurology·S YazullaD G Deutsch
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·A StraikerG Maguire
Apr 13, 2000·The European Journal of Neuroscience·A PorcellaL Pani
May 17, 2000·The Journal of Comparative Neurology·G CasiniD W Rickman
Aug 10, 2000·The Journal of Biological Chemistry·K R KozakL J Marnett
Sep 21, 2000·The European Journal of Neuroscience·N HájosT F Freund
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B F CravattA H Lichtman
Jul 13, 2002·The Journal of Comparative Neurology·Mathias BergmannAndreas Jeromin
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·T P DinhD Piomelli
Nov 28, 2002·The Journal of Comparative Neurology·Liquan HuangThomas Euler
Jan 1, 2003·The Journal of Comparative Neurology·Silke HaverkampHeinz Wässle
Sep 4, 2003·The Journal of Biological Chemistry·Malcolm BeggGeorge Kunos
Nov 25, 2003·The Journal of Biological Chemistry·Yasuo OkamotoNatsuo Ueda
Dec 23, 2003·The Journal of Comparative Neurology·Krishna K GhoshHeinz Wässle

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Citations

May 16, 2013·PloS One·Nawal Zabouri, Silke Haverkamp
Feb 18, 2016·Neural Plasticity·Elizabeth A CairnsMelanie E M Kelly
Feb 18, 2016·Neural Plasticity·Thomas SchwitzerVincent Laprevote
Feb 18, 2016·Neural Plasticity·Despina KokonaKyriaki Thermos
Feb 4, 2016·Neural Plasticity·Jean-François BouchardWilliam John Redmond
Jan 5, 2013·Journal of Neurochemistry·Lawrence C BlumeAllyn C Howlett
Mar 7, 2013·British Journal of Pharmacology·Meggie D CaldwellAlex Straiker
Feb 6, 2015·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Xiaona ZhengMorioh Kusakabe
Oct 10, 2013·British Journal of Pharmacology·N MurataevaK Mackie
Apr 23, 2014·European Journal of Pharmacology·Jessica MacIntyreMelanie E M Kelly
Oct 4, 2016·Frontiers in Pharmacology·James T ToguriMelanie E M Kelly
Dec 28, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunes PanahiMahdi Vazirian
Apr 25, 2019·Molecular Neurobiology·Estefanía Chamorro AguirreSusana J Pasquaré
Feb 7, 2015·Molecular Pharmacology·Tricia H SmithDana E Selley
Sep 3, 2011·The Journal of Pharmacology and Experimental Therapeutics·Brian D HudsonMelanie E M Kelly
Mar 10, 2020·Investigative Ophthalmology & Visual Science·Alex H VielmaAndrés E Chávez
Oct 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lisa KlotzRalf Enz
Nov 14, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Elizabeth A CairnsMelanie E M Kelly
Apr 28, 2020·Human Molecular Genetics·Karina LezirovitzJeanne Oiticica
Dec 3, 2020·Biomolecules·Emily E OliverAllyn C Howlett
Jul 27, 2021·Frontiers in Neural Circuits·Thomas Heinbockel, Alex Straiker

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