Architecture of cell-cell adhesion mediated by sidekicks

Proceedings of the National Academy of Sciences of the United States of America
Hua TangYongning He

Abstract

Cell-cell adhesion is important for cell growth, tissue development, and neural network formation. Structures of cell adhesion molecules have been widely studied by crystallography, revealing the molecular details of adhesion interfaces. However, due to technical limitations, the overall structure and organization of adhesion molecules at cell adhesion interfaces has not been fully investigated. Here, we combine electron microscopy and other biophysical methods to characterize the structure of cell-cell adhesion mediated by the cell adhesion molecule Sidekick (Sidekick-1 and Sidekick-2) and obtain 3D views of the Sidekick-mediated adhesion interfaces as well as the organization of Sidekick molecules between cell membranes by electron tomography. The results suggest that the Ig-like domains and the fibronectin III (FnIII) domains of Sidekicks play different roles in cell adhesion. The Ig-like domains mediate the homophilic transinteractions bridging adjacent cells, while the FnIII domains interact with membranes, resulting in a tight adhesion interface between cells that may contribute to the specificity and plasticity of cell-cell contacts during cell growth and neural development.

References

Jan 1, 1983·Progress in Lipid Research·S J Fliesler, R E Anderson
Jan 1, 1997·Annual Review of Cell and Developmental Biology·F S Walsh, P Doherty
Oct 26, 2000·Trends in Cell Biology·D L BensonG W Huntley
Dec 26, 2001·The Journal of Biological Chemistry·Beat KunzPeter Sonderegger
Feb 25, 2003·Annual Review of Neuroscience·Genevieve Rougon, Oliver Hobert
Oct 4, 2003·Science·Wanzhong HeDavid L Stokes
Feb 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kayo HayashiPaul E Klotman
Feb 20, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lewis KaufmanPaul E Klotman
Sep 4, 2007·Protein Science : a Publication of the Protein Society·Mario MörtlWolfram Welte
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Samuel Bouyain, Dara J Watkins
Jun 22, 2010·The Journal of Biological Chemistry·Lewis KaufmanPaul E Klotman
Sep 28, 2010·Methods in Cell Biology·Kent McDonaldMary Morphew
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahito Yamagata, Joshua R Sanes
Apr 2, 2013·Neuropharmacology·Agnes Thalhammer, Lorenzo A Cingolani
May 18, 2013·Methods in Molecular Biology·Magdalena M JulkowskaChrista Testerink
Dec 21, 2013·Methods in Molecular Biology·Wanzhong He, Yongning He
Jan 5, 2016·Structure·Matthieu ChaventMark S P Sansom
Sep 20, 2016·ELife·Kerry M GoodmanLawrence Shapiro
Nov 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Guangtao LiErwin London
Apr 21, 2017·Annual Review of Biochemistry·Catherine M Oikonomou, Grant J Jensen
May 31, 2017·Current Opinion in Neurobiology·Kai Zinn, Engin Özkan

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Citations

Jun 27, 2020·Soft Matter·Hannes WittAndreas Janshoff
Aug 25, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Tara M Finegan, Dan T Bergstralh
Jan 29, 2019·Frontiers in Molecular Neuroscience·Masahito Yamagata, Joshua R Sanes
Aug 28, 2020·Frontiers in Molecular Biosciences·Lucas M P ChataignerBert J C Janssen
Sep 29, 2020·Frontiers in Molecular Neuroscience·Masahito Yamagata
Sep 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Luqiang GuoYongning He

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