Arcobacter spp. possess two very short flagellins of which FlaA is essential for motility

FEMS Immunology and Medical Microbiology
Hoa T K HoWim Gaastra

Abstract

Like Campylobacter and Helicobacter spp., Arcobacter spp. possess two flagellin genes (flaA and flaB) located adjacent to each other. The aim of this study was to characterize the flagellin proteins of Arcobacter spp., because these proteins are known virulence factors in the Epsilonproteobacteria, to which these three species belong. With the exception of Arcobacter nitrofigilis, Arcobacter flagellins are almost half the size of those in other Epsilonproteobacteria. Arcobacter flagellin proteins lack a large part of the variable central region. The low homology observed among flagellins of different Arcobacter species indicates genetic heterology between the members of this genus. Unlike in other Epsilonproteobacteria, the transcription of flagellin genes is not regulated by sigma 28- or sigma 54-dependent promoters, which suggests that transcription must be regulated in a different way in Arcobacter spp. Mutational studies revealed that only FlaA is needed for the motility of Arcobacter spp. Quantitative PCR analysis showed that transcription of flaB is higher at 30 degrees C than at 37 degrees C. Mutation of flaB had no effect on motility or on flaA transcription while mutation of flaA abolished motility and increased the tr...Continue Reading

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Citations

Jan 15, 2011·Clinical Microbiology Reviews·Luis Collado, Maria José Figueras
Oct 3, 2012·PloS One·Irati Martinez-MalaxetxebarriaMarc M S M Wösten
Sep 24, 2014·International Journal of Medical Microbiology : IJMM·Jennifer zur BrueggeSoroush Sharbati
Jun 5, 2016·Veterinary Microbiology·Mehmet Nuri AçikBurhan Çetinkaya

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