Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Jing YangChuan Wang

Abstract

Arctigenin (ATG) has been shown to possess anti-inflammatory, immunemodulatory, anti-viral, anti-microbial, anti-carcinogenic, vasodilatory and anti-platelet aggregation properties. However, the protective role of ATG in prevention of arrhythmias induced by myocardial ischemia/reperfusion is unknown. The aim of this study was to investigate the anti-arrhythmia effect of ATG in an ischemia/reperfusion injured rat heart model and explore the related mechanisms. Rats were randomly exposed to sham operation, myocardial ischemia/ reperfusion (MI/R) alone, ATG+ MI/R, pretreated with ATG in low (12.5 mg/kg/day), medium (50 mg/kg/day) and high dose (200 mg/kg/day), respectively. Ventricular arrhythmias were assessed. The activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and the level of malondialdehyde (MDA) in myocardial tissue were determined by chemical analysis. Compared to MI/R, rats pretreated with ATG in doses of 50 mg/kg/day and 200 mg/kg/day showed significantly reduced incidence and duration of ventricular fibrillation, ventricular tachycardia and ventricular ectopic beat (VEB), and decreased the arrhythmia score during the 30-min ischemia. Incidence and duration of ventricular tachycardia, infarction si...Continue Reading

Citations

Feb 25, 2020·Journal of Cellular and Molecular Medicine·Shangkun TangHaixiao Liu
Jun 17, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Cui WenJianpeng Zhou
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Liangkai ChengCaiyan Wang
Feb 27, 2021·Molecular and Cellular Biochemistry·Violetta Krajka-KuźniakWanda Baer-Dubowska
Apr 25, 2021·Phytotherapy Research : PTR·Abu Mohammad SyedBidya Dhar Sahu
May 9, 2021·Environmental Science and Pollution Research International·Thoria Donia, Abeer Khamis
Dec 31, 2021·Archiv der Pharmazie·Grigory V Mokrov
Jul 17, 2020·Journal of Traditional and Complementary Medicine·Ahmad BeikHamid Najafipour

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