ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis

Cell Death & Disease
Yu ZhangChunlai Nie

Abstract

The expression of IκB kinase β (IKKβ) promotes the growth of breast cancer cells. Meanwhile, IKKβ mediates the phosphorylation and subsequent degradation of arrest-defective protein 1 (ARD1). However, the relationship between IKKβ and ARD1 in the occurrence of breast cancer has not been reported. In this study, we found that IKKβ not only acts directly on mammalian target of rapamycin (mTOR) activity but also indirectly acts on mTOR activity through posttranscriptional modification of ARD1, thereby effectively promoting the growth of breast cancer cells. ARD1 prevents mTOR activity and breast cancer cell growth by stabilizing tuberous sclerosis complex 2 (TSC2) to induce autophagy. Moreover, acetylation of heat shock protein 70 (Hsp70) also contributes to ARD1-mediated autophagy. Therefore, upstream IKKβ can further promote the occurrence of breast cancer by mediating the function of ARD1.

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Citations

Dec 10, 2019·Archives of Pharmacal Research·Prerna ChaudharyJi Hae Seo
Sep 5, 2020·Pharmacogenomics and Personalized Medicine·Yang GongJinfei Chen
Oct 29, 2020·Journal of Experimental & Clinical Cancer Research : CR·Tiansheng LiYongguang Tao
Mar 5, 2021·Cancer Management and Research·Lichun SunYan Zeng

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Methods Mentioned

BETA
nuclear translocation
acetylation
Assay
immunoprecipitation assay
coimmunoprecipitation
immunoprecipitation
xenograft
transfection
protein folding
acetylating

Software Mentioned

SPSS

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