Ardisinones A-E, novel diarylundecanones from Ardisia arborescens

Journal of Natural Products
Ying ZhengFeng-E Wu

Abstract

A phytochemical study on an ethanol extract of Ardisia arborescens resulted in the isolation of five new diarylundecanones, named ardisinones A-E (1-5). The structures were established by HRESIMS and NMR ((1)H, (13)C, DEPT, HSQC, HMBC) as 11-(2-acetoxy-6-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)undecan-1-one (1), 11-(2-acetoxy-6-hydroxyphenyl)-1-(2,6-dihydroxy-4-methoxyphenyl)undecan-1-one (2), 1-(2,6-dihydroxy-4-methoxyphenyl)-11-(2,6-dihydroxyphenyl)undecan-1-one (3), 1-(2,4,6-trihydroxyphenyl)-11-(2,6-dihydroxyphenyl)undecan-1-one (4), and 1-(2,4,6-trihydroxyphenyl)-11-(2-hydroxyphenyl)undecan-1-one (5). In our in vitro disk diffusion assay, compounds 1 and 4 showed some slight inhibition of three bacteria, while 2 and 3 did not show antimicrobial activity.

Citations

Mar 1, 1991·Chemistry and Physics of Lipids·P K Kinnunen
Dec 28, 2004·Journal of Ethnopharmacology·Hideka Kobayashi, Elvira de Mejía
Oct 19, 2011·Toxicology Mechanisms and Methods·Elvira González de Mejía, Marco Vinicio Ramírez-Mares
Mar 29, 2007·Natural Product Reports·Brent R Copp, A Norrie Pearce
Sep 22, 2007·Journal of Asian Natural Products Research·Ying Zheng, Feng-E Wu
Jul 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pei Lou WongFaridah Abas

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