PMID: 11910730Mar 26, 2002Paper

ARDS. The future

Critical Care Clinics
Hector R Wong

Abstract

Improving the course and outcome of patients with ARDS presents a considerable challenge. An important component of meeting this challenge is a more comprehensive understanding of the heterogeneous pathophysiology of ARDS and the biologic response of the individual patient. This understanding may be developed through the power of genomics and its related technology. In particular, it will be crucial to characterize the immunophenotypes of individual patients with ARDS. By understanding the immune status of a given patient at a given point in the disease process, physicians can consider manipulating proinflammatory systems more rationally, such as the complement and chemokine cascades, or the anti-inflammatory arm of the immune system. Finally, a more refined molecular and genetic understanding of endogenous cytoprotective molecules and mechanisms, such as the heat shock response and HO-1, may provide further tools in the future armamentarium against ARDS.

References

Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Nov 1, 1995·American Journal of Respiratory Cell and Molecular Biology·L OtterbeinA M Choi
Jan 1, 1993·The American Review of Respiratory Disease·J VillarA S Slutsky
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jul 15, 1996·The Journal of Clinical Investigation·M S MulliganP A Ward
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·P J LeeA M Choi
Dec 1, 1996·American Journal of Respiratory Cell and Molecular Biology·H R WongB R Pitt
Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·T S Blackwell, J W Christman
Sep 1, 1997·The Journal of Clinical Investigation·H BöhrerP P Nawroth
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·S L HuangS C Chang
Feb 12, 1998·The New England Journal of Medicine·A D Luster
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Sep 12, 1998·Nature Medicine·M P SoaresF H Bach
Jan 23, 1999·Current Opinion in Oncology·J L DeRisi, V R Iyer
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·A B LentschP A Ward
May 27, 1999·Journal of Biomedical Science·B R Jordan
Jun 4, 1999·The Annals of Thoracic Surgery·M HiratsukaG A Patterson
Aug 18, 1999·Annals of Surgery·M MajetschakF Stüber
Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·Y KohW D Kim

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Citations

Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christiane NeuhofHeinz Neuhof
Jul 16, 2005·Acta chirurgica Iugoslavica·V BumbasirevićVitomir Ranković
Jun 9, 2005·Srpski arhiv za celokupno lekarstvo·Ljubica ArsenijevićZvedana Kojić
Mar 16, 2006·Journal of Intensive Care Medicine·Randeep S JawaMerril T Dayton
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajesh AnejaHector R Wong

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