Are 1 or 2 dangerous? Clozapine and olanzapine exposure in toddlers

The Journal of Emergency Medicine
David C Wong, Liesl A Curtis

Abstract

Clozapine (Clozaril) and olanzapine (Zyprexa) are two relatively new atypical antipsychotics that are structurally and pharmacologically related. There are currently no therapeutic indications for these pharmaceuticals in infants and toddlers.Presumably, as the usage of these medications in adults increases, the frequency of unintentional pediatric ingestions will increase. In 2001 the annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System included a separate subcategory for atypical antipsychotics under the heading of sedatives/hypnotics/antipsychotics. The toxidrome resulting from these drugs is predominately central nervous system depression and anticholinergic effects. Although the desirable lack of extrapyramidal symptoms in adults results in their greatest clinical utility, several reports of toxic ingestions in small children are noteworthy for having extrapyramidal manifestations. We review here the available reported clinical experience with toxic doses of these medications that in small children may amount to as little as a single tablet. Although such doses may be lethal, supportive care and gastrointestinal decontamination in this population will generally lead to a go...Continue Reading

References

Sep 1, 1996·The American Journal of Emergency Medicine·S MadyR Love
Nov 13, 1998·The American Journal of Psychiatry·R A ChambersG Weiss
Jan 9, 1999·Pediatrics·L YipK Graham
Jul 29, 1999·Annals of Emergency Medicine·G F O'MalleyR C Dart
Jul 29, 1999·Annals of Emergency Medicine·G R Bond, J D Thompson
Jan 12, 2000·Journal of Child and Adolescent Psychopharmacology·G CatalanoA S Butera
May 1, 2001·Journal of Toxicology. Clinical Toxicology·M J Burns
May 10, 2001·The International Journal of Neuropsychopharmacology·Margred M. CapelJohn A. Henry

❮ Previous
Next ❯

Citations

Dec 29, 2013·European Journal of Pediatrics·Marianne MeliAlessandro Ceschi
Sep 21, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Gina Stassinos, Wendy Klein-Schwartz
Jan 3, 2021·Pediatrics in Review·David C SheridanB Zane Horowitz
May 19, 2021·Journal of Pharmacy Practice·Natalija M FarrellSara K Lookabill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Pediatric Clinics of North America
Keith Henry, Carson R Harris
The Journal of Emergency Medicine
Tenny J ThomasJeffrey N Love
Pediatric Emergency Care
J PershadM Nichols
The Journal of Emergency Medicine
Deepak K Sachdeva, John M Stadnyk
© 2021 Meta ULC. All rights reserved