Are 10-, 10-12-, or > 12-mm prostate biopsy core quality control cutoffs reasonable?

World Journal of Urology
Brunno C F SanchesLeonardo Oliveira Reis

Abstract

To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. Assessed 2424 prostate biopsy cores and corresponding RP of 202 patients submitted to the first set of 12 cores prostate biopsy between 2010 and 2015. Analyzed biopsy core length, age, prostate volume (PV), free and total PSA ratio, PSA density, RP index tumor clinical significance, extension, localization, surgical margins, and cancer control. Prostate biopsy confronted to surgical specimens defined Gleason grade-grouping system (1-5) agreement. Median age was 63.7 years, PSA 10.1 ng/dl, PSA density 28%, and mean follow-up 5 years. Recurrence was identified in 64 (31.7%) patients and predicted by PSA > 10 at time of diagnosis (p = 0.008), seminal vesicle invasion (p = 0.0019), core tumor percentage (p = 0.033), and tumor localization predominantly in the prostate base (p = 0017). The mean core length was longer in index tumor positive cores (p = 0.043) and in tumors classified as clinically insignificant (p = 0.011), without impact on tumor localization (basal vs apical ...Continue Reading

References

Mar 12, 2010·International Urology and Nephrology·Leonardo Oliveira ReisUbirajara Ferreira
Mar 8, 2013·BJU International·Phillip M PierorazioJonathan I Epstein
Aug 7, 2013·Virchows Archiv : an International Journal of Pathology·T Van der KwastUNKNOWN Pathology Committee of the European Randomized Study of Screening for Prostate Cancer (ERSPC)
Aug 3, 2014·World Journal of Urology·Leonardo O ReisAthanase Billis
Dec 3, 2014·The Journal of Urology·Mohit GuptaPhilipp Dahm
Apr 6, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Athanase BillisUbirajara Ferreira

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Citations

Apr 29, 2018·World Journal of Urology·Yılmaz Hasan, Dillioğlugil Özdal
Jul 3, 2019·World Journal of Urology·Michael A CerqueiraLeonardo Oliveira Reis
Apr 29, 2020·Scandinavian Journal of Urology·Wilmar Azal NetoLeonardo O Reis

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