Are activated T cells regulators of bone metabolism in children with Crohn disease?

The Journal of Pediatrics
Francisco A SylvesterTrudy Lerer

Abstract

To test the hypothesis that circulating activated T cells may release cytokines that decrease bone turnover in children with Crohn disease. Newly diagnosed Crohn disease and healthy controls of similar age were compared for bone age, bone mineral content and density, markers of bone remodeling, and serum concentration and in vitro T-cell production of receptor activator of nuclear factor kappaB ligand (RANKL), interferon (INF)-gamma, and osteoprotegerin (OPG). Newly diagnosed children with Crohn disease (n=23) had similar bone mineral density (BMD) z-scores and body mass index as the controls (n=40). Biochemical markers of bone remodeling indicated a state of low bone turnover in the Crohn disease patients compared with controls. Serum OPG (pmol/L; mean+/-SD, median) was higher (4.24+/-1.74, 3.98 vs 3.38+/-0.83, 3.41; P<.05), and serum RANKL (pmol/L) was lower in the Crohn disease patients (0.50+/-0.86, 0.28 vs 1.02+/-1.63, 0.49; P<.01), consistent with decreased bone resorption. Activated T cells from Crohn disease patients produced a higher concentration of INF-gamma (ng/microg protein) than those from controls (20.03+/-26.39, 8.70 vs 9.76+/-14.10, 6.17; P<.05). The newly diagnosed children with Crohn disease exhibited reduce...Continue Reading

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Citations

Jul 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Luisa BianchiHeidi J Kalkwarf
Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
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