Are all vaccines safe for the pregnant traveller? A systematic review and meta-analysis.

Journal of Travel Medicine
Roni NasserAmi Neuberger

Abstract

Pregnant travellers and their offspring are vulnerable to severe outcomes following a wide range of infections. Vaccine-preventable diseases can have a particularly severe course in pregnant women, but little is known about the safety of travel vaccines in pregnant women. We performed a systematic review of all published literature concerning the safety of vaccines frequently given to travellers such as yellow fever, MMR (mumps, measles and rubella), influenza, Tdap (tetanus, diphtheria and pertussis), meningococcus, hepatitis A and B, rabies, polio, typhoid fever, tick-borne encephalitis and Japanese encephalitis vaccines. We included case series, cohort studies and randomized controlled trials (RCTs). For the meta-analysis, we included only RCTs that compared the administration of a vaccine to placebo or to no vaccine. Outcome measures included severe systemic adverse events, maternal outcomes related to the course of pregnancy, neonatal outcomes and local adverse events. We calculated the risk ratio and its 95% confidence interval as the summary measure. The safety of influenza vaccine is supported by high-quality evidence. For Tdap vaccine, no evidence of any harm was found in the meta-analysis of RCTs. A slight increase in...Continue Reading

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Citations

Sep 24, 2020·Journal of Travel Medicine·Lecomte ElienHuits Ralph
Jun 9, 2021·Journal of Travel Medicine·Neuberger AmiSchwartz Eli
Jun 7, 2021·Tropical Diseases, Travel Medicine and Vaccines·Irmgard L Bauer

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