Are allogeneic and associative recognition coincident T cell paradigms?

Transplantation
J W Streilein, J Forman

Abstract

T lymphocytes are obsessed with cell surface molecules encoded by genes of the MHC, particularly class I (K/D) gene products. In one paradigm, T cells recognize and are activated by allodisparate class I antigens (allogeneic recognition); in another paradigm, T lymphocytes recognize viral antigens or haptens in the context of syngeneic class I determinants (associative recognition). Whether these paradigms are coincident, or even overlapping, is unresolved. We have studied neonatal tolerance induction among the H-2Kb parent strain and several of its class I mutants as a means of analyzing the fine discrimination potential of T cell recognition. Neonatal C57BL/6 animals were rendered tolerant of Kb mutant antigens; bm1, bm3, bm5, or bm8. Similar panels of mutant mice were rendered tolerant neonatally of the parent Kb antigen. When fully tolerant, mature animals were challenged with third-party grafts bearing related Kb alloantigenic disparities, they proved to be highly discriminant. Kb animals tolerant of bm1 or bm3 always rejected third-party grafts bearing bm3 and bm1 antigens, respectively. Similarly, the majority of Kb animals tolerant of bm5 or bm8 (and vice versa) were able to distinguish accurately the tolerated antigen ...Continue Reading

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.