Are American College of Rheumatology 50% response criteria superior to 20% criteria in distinguishing active aggressive treatment in rheumatoid arthritis clinical trials reported since 1997? A meta-analysis of discriminant capacities

Annals of the Rheumatic Diseases
C P ChungT Pincus

Abstract

To carry out a meta-analysis designed to compare the discriminant capacities of American College of Rheumatology 50% (ACR50) with 20% (ACR20) responses in clinical trials on rheumatoid arthritis reported after 1997 and to analyse whether ACR50 can be as informative as ACR20 in distinguishing active from control treatments in more recent trials. Clinical trials on rheumatoid arthritis reported since 1997 were identified, which included aggressive combinations of disease-modifying antirheumatic drugs and glucocorticoids, as well as powerful new agents-leflunomide, etanercept, infliximab, anakinra, adalimumab, abatacept, tacrolimus and rituximab. A meta-analysis of ACR20 compared with ACR50 responses for 21 clinical trials was carried out on differences in proportions of responders for active and control treatments and corresponding odds ratios (ORs). In all but one clinical trial on rheumatoid arthritis published since 1997 with data available on ACR20 and ACR50, more than 50% of patients who were ACR20 responders among those randomised to active treatment were also ACR50 responders. This phenomenon was seen for control groups in 38% of trials, many of which included treatment with methotrexate. A meta-analysis of the clinical tr...Continue Reading

References

Sep 5, 1985·The New England Journal of Medicine
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Mar 13, 1999·Annals of Internal Medicine·L W MorelandM E Weinblatt
Aug 14, 1999·Arthritis and Rheumatism·T Pincus, C M Stein
Nov 30, 2000·The New England Journal of Medicine·J M BathonB K Finck
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Sep 15, 2001·Annals of the Rheumatic Diseases·D L ScottUNKNOWN European Leflunomide Study Group
Nov 14, 2003·The New England Journal of Medicine·Joel M KremerLarry W Moreland
Dec 16, 2003·Arthritis and Rheumatism·David E YocumUNKNOWN Tcrolimus Rheumatoid Arthritis Study Group
Mar 6, 2004·Lancet·Lars KlareskogUNKNOWN TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Nov 6, 2004·Arthritis and Rheumatism·E William St ClairUNKNOWN Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset Study Grou

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Citations

Oct 30, 2009·Nature Reviews. Rheumatology·Chris Deighton
Nov 4, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jasvinder A SinghPeter Tugwell
Aug 22, 2009·Clinical Therapeutics·Martin Jan Bergman
Apr 10, 2010·BMC Musculoskeletal Disorders·Stuart SilvermanGergana Zlateva
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Jasvinder A SinghGurkirpal Singh
May 10, 2017·The Cochrane Database of Systematic Reviews·Jasvinder A SinghGeorge A Wells
May 4, 2010·The Journal of Rheumatology·Jasvinder A SinghGurkirpal Singh
Oct 19, 2010·The Journal of Rheumatology·Jasvinder A SinghMaria Angeles Lopez-Olivo
Sep 26, 2019·The Cochrane Database of Systematic Reviews·Amy S MudanoJasvinder A Singh

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