Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

Arthritis Research & Therapy
Karin BengtssonLennart T H Jacobsson

Abstract

To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyloarthritis (uSpA), compared to each other and to the general population (GP). This is a prospective nationwide cohort study. Cohorts with AS (n = 6448), PsA (n = 16,063) and uSpA (n = 5190) patients and a GP (n = 266,435) cohort, were identified 2001-2009 in the Swedish National Patient and Population registers. The follow-up began 1 January 2006, or 6 months after the first registered spondyloarthritis (SpA) diagnosis thereafter, and ended at ACS/stroke/VTE event, death, emigration or 31 December 2012. Crude and age- and sex-standardized incidence rates (SIRs) and hazard ratios (HRs) were calculated for incident ACS, stroke or VTE, respectively. Standardized to the GP cohort, SIRs for ACS were 4.3, 5.4 and 4.7 events per 1000 person-years at risk in the AS, PsA and uSpA cohort, respectively, compared to 3.2 in the GP cohort. SIRs for stroke were 5.4, 5.9 and 5.7 events per 1000 person-years at risk in the AS, PsA and uSpA cohort compared to 4.7 in the GP cohort. Corresponding SIRs for VTE were 3.6, 3.2 and 3.5 events per ...Continue Reading

References

Oct 7, 2005·American Journal of Epidemiology·Robert J Glynn, Bernard Rosner
May 9, 2006·Journal of Neurology·José M Ferro
Jun 17, 2006·Best Practice & Research. Clinical Rheumatology·Joachim SieperJürgen Braun
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Joel M GelfandAndrea B Troxel
Oct 21, 2006·Journal of the American Academy of Dermatology·Andrea L NeimannJoel M Gelfand
Oct 28, 2006·Seminars in Arthritis and Rheumatism·Oded KimhiOri Elkayam
Dec 19, 2007·Circulation·Walter AgenoPieter W Kamphuisen
Jun 21, 2008·Stroke; a Journal of Cerebral Circulation·Paul WelshMark Woodward
Sep 2, 2008·Arthritis and Rheumatism·Lai-Shan TamCheuk-Man Yu
Apr 11, 2009·Stroke; a Journal of Cerebral Circulation·Klaus Kaae AndersenLars Peter Kammersgaard
May 22, 2009·The Journal of Investigative Dermatology·Joel M GelfandAndrea B Troxel
Apr 9, 2010·Annals of the Rheumatic Diseases·Jiunn-Horng KangHerng-Ching Lin
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Sep 8, 2011·Arthritis and Rheumatism·Lotta LjungUNKNOWN Anti-Rheumatic Therapy in Sweden (ARTIS) Study Group
Dec 20, 2011·The British Journal of Dermatology·W-Q LiA A Qureshi
Apr 26, 2012·Annals of the Rheumatic Diseases·Anna JamnitskiMichael T Nurmohamed
May 23, 2012·Annals of the Rheumatic Diseases·Marie HolmqvistJohan Askling
Oct 4, 2012·JAMA : the Journal of the American Medical Association·Marie E HolmqvistJohan Askling
Apr 6, 2013·Journal of the American Heart Association·Ehrin J ArmstrongApril W Armstrong
Jul 3, 2013·Nature Reviews. Cardiology·Viola VaccarinoRaffaele Bugiardini
Sep 26, 2014·Arthritis Research & Therapy·Jason J Lee, Janet E Pope
Nov 2, 2014·Annals of the Rheumatic Diseases·Ivette EssersAstrid van Tubergen
Sep 26, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Lin LiSusan Jick

❮ Previous
Next ❯

Citations

Jul 4, 2018·Current Eye Research·Xuling ChenLiu Yang
Feb 10, 2019·Annals of the Rheumatic Diseases·Juan Antonio Aviña-ZubietaJohn Esdaile
Jul 12, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Hafid Ait-OufellaAlain Tedgui
Jan 17, 2019·The Journal of Rheumatology·Mohammad H DerakhshanUNKNOWN BRITSpA and COMOSPA Investigators
Oct 11, 2019·Current Opinion in Rheumatology·Emire Seyahi
Feb 1, 2019·Terapevticheskiĭ arkhiv·I Z GaydukovaA P Rebrov
Sep 25, 2020·International Journal of Rheumatic Diseases·Ji Hyoun Kim, In Ah Choi
Mar 17, 2020·BMC Rheumatology·Alessia AlunnoMaurizio Cutolo
Feb 1, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Anniina T VirtanenOlli Silvennoinen
Sep 7, 2020·RMD Open·Clementina López-Medina, Anna Molto
Jun 4, 2020·Continuum : Lifelong Learning in Neurology·Pantelis P Pavlakis
Mar 30, 2018·Frontiers in Medicine·Anna Moltó, Elena Nikiphorou
Apr 25, 2018·Zeitschrift für Rheumatologie·U KiltzJ Braun
Aug 2, 2020·Annals of the Rheumatic Diseases·Steven Ho Man LamLai-Shan Tam
Aug 28, 2020·Clinical Rheumatology·Anna SödergrenLennart T H Jacobsson
Jul 25, 2019·Current Vascular Pharmacology·Charalampos PapagorasAlexandros A Drosos
Feb 26, 2020·Postgraduate Medical Journal·Yong-Jun MeiZhi-Jun Li
Nov 17, 2020·Frontiers in Immunology·Ariane HammitzschPhilipp Moog
Oct 17, 2020·The Journal of Rheumatology·Shao-Hsien LiuJonathan Kay

❮ Previous
Next ❯

Software Mentioned

SPSS
SAS
PASW Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.