PMID: 22360135Mar 1, 2012Paper

Are anti-Phl p 12 IgE levels predictive of oral allergy syndrome in profilin hypersensitive patients?

European Annals of Allergy and Clinical Immunology
R Asero, D Villalta

Abstract

In birch pollen-allergic patients the occurrence of clinically relevant crossreactivity to plant-derived foods is clearly related with the level of birch-specific IgE. In profilin-hypersensitive patients this has not been investigated so far. To investigate whether the levels of profilin IgE are predictive of the development of food allergy in hypersensitive patients. IgE specific for Phl p 12, the grass pollen profilin, were measured in 37 subjects monosensitized to profilin with (n = 11) or without (n = 26) oral allergy syndrome (OAS) following the ingestion of plant-derived foods. Patients without a history of OAS showed higher levels of IgE specific for Phl p 12 than patients with OAS (median 4.74 [range 0.7-41.6] KU/L vs 2.14 [range 0.32-10.2] KU/L, respectively) although the difference did not reach statistical significance (p = 0.07). Factors causing the onset of OAS in profilin-hypersensitive patients remain presently unclear.

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Javier Cuesta-HerranzM De-Las-Heras
International Archives of Allergy and Immunology
Javier Cuesta-HerranzAna I Tabar
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
R AseroStefano Amato
© 2022 Meta ULC. All rights reserved