PMID: 3533337Oct 1, 1986Paper

Are anti-platelet drugs of value in the management of patients with chronic stable angina? A study with ticlopidine

Clinical Cardiology
N S KhurmiE B Raftery

Abstract

Thirty patients (28 males and 2 females) aged 46-68 years with established chronic stable angina were studied in a placebo-controlled double-blind crossover trial to examine the efficacy of oral ticlopidine (an antiplatelet agent) 250 mg twice daily. The baseline mean +/- SEM exercise time of 7.5 +/- 0.5 min rose to 8.1 +/- 0.6 min after 2 weeks of placebo run-in, 8.8 +/- 0.7 min after 4 weeks of double-blind placebo, and to 9.2 +/- 0.6 min with ticlopidine therapy; none of these changes achieved statistical significance. Similarly, time to the development of 1 mm ST-segment depression, maximal ST-segment depression, heart rate, and rate-pressure product failed to show any statistically significant changes during ticlopidine therapy. Ambulatory electrocardiographic monitoring showed that the mean number of episodes of ST-segment depression greater than 1 mm remained unaltered during ticlopidine therapy. Four patients (3 during placebo, 1 during ticlopidine) stopped treatment prematurely because of unstable angina and two because of adverse effects. Our data suggest that ticlopidine has no significant effect on objective indices of myocardial ischemia in patients with chronic stable angina, that placebo has no effect on the obje...Continue Reading

References

Jul 1, 1979·Progress in Cardiovascular Diseases·A I Schafer, R I Handin
Mar 1, 1977·The American Journal of Cardiology·S J Schang, C J Pepine
Mar 1, 1979·The American Journal of Cardiology·A P SelwynG Forse
Jun 1, 1978·Thrombosis Research·M TomikawaY Abiko
Aug 1, 1978·Thrombosis Research·J R O'BrienR D Shuttleworth
Oct 2, 1982·Lancet·K M FoxA P Selwyn
Dec 1, 1984·The American Journal of Cardiology·J E DeanfieldA P Selwyn
Aug 1, 1984·International Journal of Cardiology·N S KhurmiE B Raftery
Apr 1, 1983·Journal of the American College of Cardiology·V Bala SubramanianE B Raftery
Oct 1, 1982·The American Journal of Cardiology·V B SubramanianE B Raftery
Jun 1, 1980·British Heart Journal·A Maseri
Oct 1, 1980·British Heart Journal·V BalasubramanianE B Raftery

Citations

Jan 1, 1988·The American Journal of Cardiology·N S Khurmi, E B Raftery
Mar 1, 1990·Journal of Gerontological Nursing·D M GregoryC F Cameron
Jul 1, 1993·British Journal of Obstetrics and Gynaecology·S C RobsonM de Swiet
Dec 2, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·P Engelfriet, B J M Mulder
Sep 1, 1993·The Annals of Pharmacotherapy·P Flores-Runk, R H Raasch

Related Concepts

Angina Pectoris
Clinical Trials
Double-Blind Method
Electrocardiographic Recorders
Cardiopulmonary Exercise Test
Platelet Aggregation
Ticlid

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.