Are antiangiogenics a good 'partner' for immunotherapy in ovarian cancer?

Angiogenesis
Elena García-MartínezAntonio Casado

Abstract

Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune responses in the peritoneal cavity and tumor microenvironment (TME) affect neovascular formation. Therefore, suppressing the angiogenic pathways could facilitate the arrival of immune effector cells and reduce the presence of myeloid cells involved in immune suppression. To date, clinical studies have shown significant benefits with antiangiogenic therapy as first-line therapy in OC, as well as in recurrent disease, and the vascular endothelial growth factor (VEGF) inhibitor bevacizumab is now an established therapy. Clinical data with immunomodulators in OC are more limited, but suggest that they could benefit some patients with recurrent disease. The preliminary results of two phase III trials have shown that the addition of immunomodulators to chemotherapy does not improve progression-free survival. For this reason, it could be interesting to look for synergistic effects between immunomodulators and other active drugs ...Continue Reading

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Citations

Mar 17, 2021·Immunobiology·Alexandra GiatromanolakiMichael I Koukourakis
Aug 7, 2021·Biomolecules·Chao-Lien LiuTsui-Lien Mao

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Methods Mentioned

BETA
lavage
biopsy

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NCT03038100
NCT02891824
NCT03596281
NCT03353831
NCT03574779
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NCT02923739
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