PMID: 9183201May 24, 1997Paper

Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis

BMJ : British Medical Journal
C Del MarM Hayem

Abstract

To determine the effect of antibiotic treatment for acute otitis media in children. Systematic search of the medical literature to identify studies that used antibiotics in randomised controlled trials to treat acute otitis media. Studies were examined blind, and the results of those of satisfactory quality of methodology were pooled. Six studies of children aged 7 months to 15 years. Pain, deafness, and other symptoms related to acute otitis media or antibiotic treatment. 60% of placebo treated children were pain free within 24 hours of presentation, and antibiotics did not influence this. However, at 2-7 days after presentation, by which time only 14% of children in control groups still had pain, early use of antibiotics reduced the risk of pain by 41% (95% confidence interval 14% to 60%). Antibiotics reduced contralateral acute otitis media by 43% (9% to 64%). They seemed to have no influence on subsequent attacks of otitis media or deafness at one month, although there was a trend for improvement of deafness at three months. Antibiotics were associated with a near doubling of the risk of vomiting, diarrhoea, or rashes (odds ratio 1.97 (1.19 to 3.25)). Early use of antibiotics provides only modest benefit for acute otitis me...Continue Reading

Citations

Mar 25, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R Dagan
Apr 1, 1998·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·A K Bhattacharyya, S Ghodh
Mar 15, 2002·Current Allergy and Asthma Reports·A Gungor, C D Bluestone
Jun 7, 2003·Current Allergy and Asthma Reports·William J Doyle, Cuneyt M Alper
Jun 7, 2003·Current Allergy and Asthma Reports·Craig A Buchman, George M Brinson
Jul 11, 2006·Current Allergy and Asthma Reports·Deborah Gentile
Aug 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Bobak A GhaheriDennis R Trune
Mar 16, 2001·International Journal of Pediatric Otorhinolaryngology·R M Rosenfeld
May 30, 2001·International Journal of Pediatric Otorhinolaryngology·M Foglé-HanssonK Prellner
May 8, 2002·Social Science & Medicine·Matthew D CurryChristopher J Mansfield
Apr 3, 2001·International Journal of Antimicrobial Agents·S EspositoP Tonelli
May 3, 2003·Homeopathy : the Journal of the Faculty of Homeopathy·Petter Viksveen
Jul 20, 2012·The Journal of Laryngology and Otology·Edward C Toll, Desmond A Nunez
Aug 14, 2002·Journal of Paediatrics and Child Health·V A MoyerE J Elliott
Jun 2, 2001·The New England Journal of Medicine·E I Cantekin
Oct 11, 2002·The New England Journal of Medicine·J Owen Hendley
Jan 14, 2011·The New England Journal of Medicine·Paula A TähtinenAino Ruohola
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J P Ioannidis, J Lau
Mar 15, 2001·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·J MorleyD Redwood
Sep 17, 2010·Family Practice·Cindy L K Lam
Oct 13, 2006·Current Opinion in Infectious Diseases·A Villaseñor-SierraS Preciado
Sep 24, 1999·The Pediatric Infectious Disease Journal·J D Seidel
May 3, 2006·Pediatric Emergency Care·Lisa M Elden, David M Spiro
May 20, 2011·The Pediatric Infectious Disease Journal·Carlos Eladio ArmengolBirgit Winther
Jul 5, 2012·The Pediatric Infectious Disease Journal·Paula A TähtinenAino Ruohola
Sep 17, 2009·Pediatric Emergency Care·Thomas FischerStuart Chale
Nov 4, 2000·Australian Dental Journal·T JaunayA Goss
Mar 31, 1998·BMJ : British Medical Journal·T Fahey, D Sharp
Dec 6, 2001·The Western Journal of Medicine·S Pirozzo, C Del Mar
Jan 31, 2007·Annals of Family Medicine·Andrew S Coco
May 26, 2007·PLoS Clinical Trials·Robert L DavisDimitri A Christakis
Jul 21, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Anita L KozyrskyjBarbara J Law
Feb 3, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Nicole Le SauxDavid Moher
Mar 3, 2010·Pediatrics in Review·Jane M Gould, Paul S Matz

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