Are antibiotics related to oral combination contraceptive failures in the Netherlands? A case-crossover study

Pharmacoepidemiology and Drug Safety
Petra C KoopmansLolkje T W de Jong van den Berg

Abstract

To investigate whether there is an association between use of antibiotics and breakthrough pregnancy. The study was performed in a population-based prescription database (IADB.nl). We computed case-crossover odds ratios of 397 cases of defined breakthrough pregnancy comparing the use of antibiotics in the exposure window with the use of antibiotics in two control windows. We defined a control group consisting of 29 022 other pregnancies. We computed case-control odds ratios of the use of antibiotics in cases as compared with controls in the different time windows. The case-crossover odds ratios comparing the use of antibiotics in the exposure window with both control windows were 2.21 (95%CI = 1.03-4.75) and 1.65 (95%CI = 0.78-3.48), respectively. The traditional case-control odds ratios after adjustment for age were 1.71 (95%CI = 1.09-2.66) in the exposure window, 0.81 (95%CI = 0.44-1.47) 2 months before the exposure window, and 1.04 (95%CI = 0.61-1.78) 12 months before the exposure window. We did find a relationship between the use of antibiotics and breakthrough pregnancy in a population-based prescription database. The results did not hold for broad-spectrum antibiotics or in a sensitivity analysis. The results are partly n...Continue Reading

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Citations

Sep 21, 2013·The Nurse Practitioner·Danielle Well
Aug 21, 2013·European Journal of Public Health·Kathryn HoffmannManfred Maier
Feb 19, 2015·Pharmacoepidemiology and Drug Safety·Iain A GillespieUNKNOWN ARO Steering Committee
Apr 7, 2015·The Medical Clinics of North America·Ginger Evans, Eliza L Sutton
Jul 12, 2017·American Journal of Obstetrics and Gynecology·Katharine B SimmonsKathryn M Curtis
Mar 6, 2018·Basic & Clinical Pharmacology & Toxicology·Anton PottegårdPer Damkier

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