Are antisperm antibodies really associated with proven chronic inflammatory and infectious diseases of the male reproductive tract?

European Urology
Marcelo MarconiW Weidner

Abstract

It is debated whether chronic urogenital inflammations and infections may trigger the formation of antisperm antibodies (ASA) in semen. To evaluate the formation of ASA in defined chronic inflammatory and infectious diseases of the male reproductive tract (MRT). Three hundred sixty-five patients retrospectively enrolled in a single center were categorized as having National Institutes of Health (NIH) category II chronic prostatitis (n=38), NIH category IIIa chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) (n=59), NIH category IIIb CP/CPPS (n=213), chronic epididymitis (n=34), and chronic urethritis (n=21). Forty-five age-matched men served as controls. All subjects underwent microbiologic and cytologic analysis for common bacteria, yeasts, and mycoplasma using the four-glass test. Urine samples, ejaculates, and urethral swabs were analyzed with polymerase chain reaction (PCR) for Chlamydia trachomatis and Neisseria gonorrhea. Semen analysis followed World Health Organization (WHO) standards. ASA in seminal plasma were analyzed using the mixed agglutination reaction (MAR) test. The overall positive detection rate of clinically significant levels (> or = 50% of spermatozoa coated by ASA) of IgG and IgA antibodies was 1....Continue Reading

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Citations

May 8, 2010·Der Urologe. Ausg. A·H-C SchuppeW Weidner
Jul 17, 2013·World Journal of Urology·W WeidnerF Wagenlehner
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Sep 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yuki KatoAtsushi Mizokami

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