Are beta-adrenergic receptors in the hippocampal CA1 region required for retrieval of contextual fear memory?

Biochemical and Biophysical Research Communications
Xue-Lian QiBao-Ming Li

Abstract

It is well established that beta-adrenoceptors (beta-ARs) in the hippocampal CA1 region are involved in regulating synaptic plasticity and are essential for acquisition and consolidation of spatial memory and contextual fear memory. Previous studies reported that beta-ARs in the CA1 region are also involved in memory retrieval. The present study re-examined the role of hippocampal beta-ARs in retrieval of conditioned contextual fear. We bilaterally infused a high dose of the beta-AR antagonist propranolol (15mug in 1mul saline) into the CA1 region 30min before retention test and found that propranolol produced no deficit in retrieval of either 1-day or 7-day contextual fear. We then examined if beta-AR stimulation would produce a beneficial effect. The beta-AR agonist isoproterenol (10mug in 1mul saline) was infused into the CA1 region 30min before retention test. Surprisingly, isoproterenol did not enhance but severely disrupted retrieval of 7-day contextual fear memory, with no impact on retrieval of 1-day contextual fear memory. The present study argues against the previous conclusion that beta-ARs in the CA1 region play a role in memory retrieval. beta-ARs in the CA1 region may be dispensable for retrieval of conditioned co...Continue Reading

References

Apr 8, 1998·Annual Review of Neuroscience·A J SilvaS Kida
Jan 15, 2000·Science·J L McGaugh
Mar 23, 2001·Hippocampus·L R SquireB J Knowlton
May 20, 2003·The European Journal of Neuroscience·Jin-Zhao JiBao-Ming Li
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Daniela M BarrosIvan Izquierdo
Apr 7, 2004·Cell·Charles F MurchisonSteven A Thomas

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Citations

Aug 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Carolina Garrido ZinnIvan Izquierdo
Mar 27, 2021·Biological Psychiatry·Sofia Leal SantosChristine A Denny
Aug 22, 2021·Behavioural Pharmacology·Stephanie L GrellaDiano F Marrone

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