PMID: 10938496Aug 12, 2000Paper

Are beta-blockers effective in patients who develop heart failure soon after myocardial infarction? A meta-regression analysis of randomised trials

European Journal of Heart Failure
T HoughtonJ G Cleland

Abstract

The great majority of post-infarction studies of beta-blockers were conducted in an era when these agents were widely held to be contra-indicated for the management of heart failure. We now know that beta-blockers are highly effective for the management of patients with chronic stable heart failure. However, there remains uncertainty about their role in the setting of post-infarction heart failure and ventricular dysfunction. the primary objective in this paper, was to investigate the extent to which heart failure or evidence of major cardiac dysfunction influenced outcome in previous trials of beta-blockers in heart failure after myocardial infarction. We assessed the extent to which the inclusion of patients with heart failure or major cardiac dysfunction influenced outcome in randomised trials of long-term use of beta-blockade after myocardial infarction. The primary analysis was to assess the extent to which the proportion of patients included in each trial with heart failure influenced the relative odds of all-cause mortality in the trials. All randomised trials without crossover with treatment lasting more than one month and with 50 or more patients were considered. All those that provided information on the proportion of...Continue Reading

References

Aug 1, 1977·British Journal of Clinical Pharmacology·D G McDevitt
Aug 1, 1990·The American Journal of Cardiology·J P BoisselJ C Peyrieux
Sep 25, 1990·The American Journal of Cardiology·J P BoisselT Ducruet
Jun 1, 1985·Journal of the American College of Cardiology·G OlssonT Lundman
Mar 26, 1983·British Medical Journal·J FeelyD Maclean
Apr 30, 1983·British Medical Journal·C M Kaye
May 21, 1983·British Medical Journal
Nov 18, 1982·The New England Journal of Medicine·S H TaylorD M Burley
Apr 2, 1981·The New England Journal of Medicine·UNKNOWN Norwegian Multicenter Study Group
Mar 26, 1982·JAMA : the Journal of the American Medical Association
Dec 30, 1995·Statistics in Medicine·T C SmithA Thomas
Mar 26, 1999·BMJ : British Medical Journal·J G ClelandN Freemantle
Apr 6, 1999·The American Journal of Cardiology·T E DeleaG Oster
Jun 25, 1999·BMJ : British Medical Journal·N FreemantleJ Harrison

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Citations

Apr 7, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·John G F ClelandMansour Nasir
Aug 9, 2002·European Journal of Heart Failure·Christian Torp-PedersenJan Carlsen
Dec 13, 2000·European Journal of Heart Failure·K WitteJ G Cleland
Aug 25, 1999·Lancet·J LindsayI Nazareth
Nov 30, 2002·Lancet·J G F ClelandUNKNOWN Study Group on Diagnosis of the Working Group on Heart Failure of The European Society of Cardiology
Jul 9, 2010·Best Practice & Research. Clinical Anaesthesiology·Daniel Chappell, Matthias Jacob
Oct 19, 2006·Progress in Cardiovascular Diseases·Gurusher S Panjrath, Franz H Messerli
Mar 28, 2007·Heart Failure Clinics·John G F ClelandJonathan Windram
Mar 17, 2004·The American Journal of Medicine·Liviu Klein, Mihai Gheorghiade
Jul 21, 2006·Best Practice & Research. Clinical Anaesthesiology·Jørn Wetterslev, Anne Benedicte Juul
Jan 28, 2015·Lancet·John J V McMurray, Dirk J van Veldhuisen
Oct 20, 2009·Journal of Hypertension·Giuseppe ManciaUNKNOWN European Society of Hypertension
May 18, 2001·Current Opinion in Cardiology·M Tendera, A Ochala
Jan 25, 2003·BMC Public Health·Richard F HellerPatrick McElduff
Feb 3, 2006·Clinical Cardiology·James A ReiffelUNKNOWN American College of Cardiology
Apr 30, 2010·Expert Opinion on Pharmacotherapy·Wilbert S Aronow

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