Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis

American Journal of Clinical Dermatology
Igor SnastYael Anne Leshem

Abstract

Current systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics. The aim of this study was to evaluate the efficacy and safety of biologic agents in AD. A systematic review and meta-analysis of studies evaluating AD patients treated with biologics was performed. The primary outcome was the Eczema Area and Severity Index (EASI)-75 response, while secondary outcomes were SCOring Atopic Dermatitis (SCORAD)-75, EASI-50, SCORAD-50, Investigator Global Assessment 0/1 responses, change in responses from baseline, and adverse events. We included 13 randomized controlled trials (RCTs) and 10 observational studies evaluating nine biologics. High-quality evidence was available for dupilumab, nemolizumab and ustekinumab. Pooling five studies, at weeks 12-16 dupilumab 300 mg every week to every 2 weeks achieved EASI-75 responses of 55%, superior to placebo [relative risk (RR) 3.3, 95% confidence interval (CI) 2.9-3.6]. Nemolizumab had similar EASI-75 responses as placebo, but significantly improved pruritus. In online reports, lebrikizumab demonstrated superior EASI-50 responses versus placebo (RR 1.3, 95% CI 1.04-1.7...Continue Reading

References

Dec 10, 1999·Nature·D B Corry, F Kheradmand
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Gurjit K Khurana Hershey
Mar 12, 2005·Journal of the American Academy of Dermatology·Arnd JacobiMichael Hertl
Jun 20, 2006·Journal of the American Academy of Dermatology·Paul G VigoIftikhar Hussain
Apr 11, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·John P A Ioannidis, Thomas A Trikalinos
Oct 16, 2007·The Journal of Allergy and Clinical Immunology·Benedetta BelloniMartin Mempel
Jan 22, 2008·The Journal of Allergy and Clinical Immunology·Dagmar SimonHans-Uwe Simon
Feb 15, 2008·The New England Journal of Medicine·Stephen L HauserUNKNOWN HERMES Trial Group
Oct 18, 2008·Allergy and Asthma Proceedings·Lee E SheinkopfWilliam B Klaustermeyer
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 18, 2009·Mucosal Immunology·M R Comeau, S F Ziegler
Aug 4, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter Maximilian HeilGeorg Stingl
Dec 3, 2010·Current Medical Research and Opinion·Henry MilgromSumedha Jayawardene
Jun 21, 2011·Immunological Reviews·Mark Boguniewicz, Donald Y M Leung
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Jul 21, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·J RingUNKNOWN Global Allergy and Asthma European Network
Oct 23, 2012·Clinical and Experimental Dermatology·D H KimS K Mun
Jul 3, 2013·International Archives of Allergy and Immunology·Shuba Rajashri IyengarKari Christine Nadeau
Oct 8, 2013·The Journal of Allergy and Clinical Immunology·Jonathan I Silverberg, Jon M Hanifin
Oct 16, 2013·Journal of the American Academy of Dermatology·Jonathan Lacombe BarriosAnne Des Roches
Nov 26, 2013·The Journal of Allergy and Clinical Immunology·Evelien RoekevischJochen Schmitt
Jul 10, 2014·The New England Journal of Medicine·Lisa A BeckAllen R Radin
Oct 6, 2014·The Journal of Allergy and Clinical Immunology·Jochen SchmittUNKNOWN HOME initiative collaborators
Dec 9, 2014·The Journal of Allergy and Clinical Immunology·Jennifer D HamiltonEmma Guttman-Yassky
Jun 6, 2015·The Journal of Investigative Dermatology·Alexander NastRicardo N Werner
Jun 11, 2015·Acta Dermato-venereologica·Alexander ZinkMarkus Ollert
Oct 3, 2015·The Journal of Allergy and Clinical Immunology·Shinji NodaEmma Guttman-Yassky
Nov 26, 2015·Immunotherapy·Jennifer D HamiltonEmma Guttman-Yassky
Jun 16, 2016·Experimental Dermatology·Saakshi KhattriEmma Guttman-Yassky
Jun 24, 2016·International Journal of Dermatology·Jesper Grønlund HolmSimon Francis Thomsen
Aug 3, 2016·International Journal of Molecular Sciences·Jung Eun KimHyun Jeong Park
Oct 4, 2016·The New England Journal of Medicine·Eric L SimpsonUNKNOWN SOLO 1 and SOLO 2 Investigators
Nov 26, 2016·The Journal of Investigative Dermatology·Laurence Le CleachLudovic Trinquart
Mar 2, 2017·The New England Journal of Medicine·Thomas RuzickaUNKNOWN XCIMA Study Group
Jul 16, 2017·Clinics in Dermatology·Yael Renert-Yuval, Emma Guttman-Yassky

❮ Previous
Next ❯

Citations

Nov 6, 2018·The Journal of Dermatological Treatment·Lucia LeonardiMarzia Duse
Feb 6, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Jesper G Holm, Simon F Thomsen
Apr 6, 2018·BioMed Research International·Giuseppe A RamirezLorenzo Dagna
Oct 2, 2019·Current Opinion in Allergy and Clinical Immunology·Antonella Cianferoni, Isabella Annesi-Maesano
Nov 23, 2019·Journal of Clinical Apheresis·Damian MeyersburgChristoph Grabmer
Jan 7, 2020·The Kaohsiung Journal of Medical Sciences·Jun-Kai KaoRei-Cheng Yang
Apr 9, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C M OlesenT Agner
May 8, 2020·Dermatologic Therapy·Mauro IannelliGiovanni B Pajno
Jan 27, 2019·Experimental and Therapeutic Medicine·Diana Deleanu, Irena Nedelea
Jul 30, 2020·The British Journal of Dermatology·V S NarayanA Wolkerstorfer
Sep 15, 2020·The Cochrane Database of Systematic Reviews·Ratree SawangjitNathorn Chaiyakunapruk
Jul 14, 2020·Allergy·Pauline AzzanoPhilippe Bégin
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Sérgio Ricardo Teixeira DaltroMilena Botelho Pereira Soares
Jul 13, 2018·Stem Cell Research & Therapy·Byong Seung ChoYong Weon Yi
Oct 20, 2020·Allergy·Doreen SiegelsUNKNOWN European Academy of Allergy, Clinical Immunology Atopic Dermatitis Guideline group
Nov 23, 2020·Archives of Dermatological Research·Marissa T AyasseJonathan I Silverberg
Dec 15, 2020·Dermatology and Therapy·Firas Constantin KreeshanHamish John Alexander Hunter
Apr 15, 2021·The Journal of Dermatological Treatment·Husein Husein-ElAhmed, Martin Steinhoff
Jun 4, 2019·Journal of the American Academy of Dermatology·Maria C SchneeweissJoseph F Merola
Nov 12, 2021·Expert Opinion on Pharmacotherapy·Vikram N SahniSteven R Feldman
Dec 18, 2021·Journal of the American Academy of Dermatology·Sarah GuoBrandon L Adler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.