Are Biologics Safe in the Immediate Postoperative Period? A Single-Center Evaluation of Consecutive Crohn's Surgical Patients

Diseases of the Colon and Rectum
Amy L LightnerEdward V Loftus

Abstract

There is no study to date examining the safety of initiating or restarting biologic therapy after major abdominal surgery for Crohn's disease. The purpose of this study was to determine differences in the rates of 90-day superficial surgical site infections, intra-abdominal sepsis, and overall postoperative infectious complications among patients who were initiated on or restarted a biologic within 90 days postoperatively compared with those who were not. This was a retrospective cohort study. The study was conducted at an IBD referral center. Adult patients with Crohn's disease who received a biologic therapy within 90 days of a major abdominal operation between May 20, 2014, and December 31, 2018, were included. Ninety-day superficial surgical site infection, intra-abdominal sepsis, and overall postoperative infectious complications were measured. A total of 680 patients with Crohn's disease were included: 351 were initiated on biologic therapy within 90 days after surgery and 329 were not. Patients exposed to biologic therapy postoperatively were younger (p < 0.001), had a lower BMI (p = 0.0014), were less often diabetic (p = 0.0011), and were more often exposed preoperatively to biologics (p < 0.0001) and immunomodulators (...Continue Reading

References

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