PMID: 2025530Jan 1, 1991

Are blood transfusions beneficial in the cyclosporine era?

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
D PotterO Salvatierra

Abstract

In patients treated with conventional immunosuppression (azathioprine and prednisone) after renal transplantation, there is a beneficial effect of pre-transplant blood transfusions on graft survival; in patients treated with cyclosporine, this effect may be lost. In 66 children who received living-related donor transplants after donor-specific transfusions (DST) and were treated with azathioprine-prednisone in our center, 1- and 5-year graft survival rates were 99% and 77% respectively. These rates were similar to those reported for children who did not receive DST but were treated with cyclosporine in other centers. There were 634 adult and pediatric recipients of cadaver transplants in our center who were treated with cyclosporine and prednisone (non-sequential therapy, n = 89) or antilymphoblast globulin, azathioprine preduisone, and cyclosporin (sequential therapy, n = 545). When all patients were considered, graft survival rates were higher in transfused than in non-transfused patients at 3-5 years, but in the sequential therapy group, there were no differences in graft survival rates between transfused and non-transfused patients. The results suggest that transfusions do not improve cadaver graft survival in patients rece...Continue Reading

References

Dec 1, 1979·Transplantation Proceedings·G OpelzC Chun
Jan 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R SchoumacherD A Spyker
Jan 1, 1987·Transplantation·B G SommerR M Ferguson
Jan 1, 1987·Neir̆ofiziologiia = Neurophysiology·E P LukhaninaN G Matiuk

Citations

Oct 1, 1995·Current Opinion in Immunology·C Clayberger, A M Krensky
Dec 16, 2006·European Journal of Immunology·Nicolas DegauqueJean-Paul Soulillou
Mar 22, 2002·Pediatric Transplantation·Peter H Lapchak, D M Briscoe
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki KitadeJacques Pirenne

Related Concepts

Blood Transfusion
Cyclosporins
Graft Survival
Kidney Transplantation

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