PMID: 9181478May 1, 1997Paper

Are Canadian Inuit at increased genetic risk for coronary heart disease?

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
R A HegeleP W Connelly

Abstract

The Keewatin Inuit of the Northwest Territories of Canada have a very low age-adjusted mortality rate from coronary heart disease. We hypothesized that this apparent protection from disease has a genetic basis. We determined the prevalence of the disease-associated alleles of five candidate genes for atherosclerosis-related phenotypes. Surprisingly, four of the five alleles studied, namely AGT T235, FABP2 T54, PON R192 and APOE E4, were significantly more frequent in a sample of 175 Keewatin Inuit than among a representative control sample of whites living in the region. The high frequencies of these disease-associated alleles suggests either that they have no relationship with disease susceptibility in the Inuit, or that some unmeasured genetic and/or environmental factors mitigate disease susceptibility that is associated with these alleles. This highlights the difficulty in extrapolating findings from one population to another. Also, very modest genotype-phenotype associations were observed between APOE genotype (P = 0.016) and plasma low-density lipoprotein cholesterol concentration and between FABP2 genotype and plasma 2-h postprandial, glucose concentration (P = 0.048). The relationship between APOE alleles and plasma low...Continue Reading

Citations

May 26, 1999·American Journal of Physical Anthropology·T K YoungJ D O'Neil
Dec 21, 2000·Current Atherosclerosis Reports·J M Ordovas, J R Galluzzi
Jan 16, 2004·Experimental Gerontology·Ildiko SeresAbdelouahed Khalil
Jan 22, 2003·Atherosclerosis·Peter BjerregaardRobert A Hegele
Jul 31, 1999·Atherosclerosis·D A BoudreauE Jul
Jul 12, 2003·Molecular Genetics and Metabolism·Natalia L DuarteDavid E L Wilcken
Oct 2, 2012·The British Journal of Nutrition·Iwona RudkowskaMarie-Claude Vohl
Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·F C Luft
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dolkun RahmutulaZhu Hen-Chen
May 3, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Elena L Grigorenko
Mar 19, 2013·Journal of Diabetes and Metabolic Disorders·Hamideh PishvaSoltan Ali Mahboob
Aug 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·S FanellaR A Hegele
Mar 30, 2012·International Journal of Circumpolar Health·Thor Munch-AndersenJørn W Helge
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A Hegele
Dec 26, 2015·International Journal of Environmental Research and Public Health·Lorena M SaltoMarino De Leon
Oct 6, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Barbara V HowardCharlotte R Wenger
Sep 1, 2015·The Canadian Journal of Cardiology·Laura ArbourRobert A Hegele
Aug 5, 2015·The Canadian Journal of Cardiology·Maria TvermosegaardMarit Eika Jørgensen
Aug 16, 2005·Annals of Human Biology·Darío A DemarchiMara H Hutz
Sep 28, 2002·Diabetes Care·Marit E JørgensenKnut Borch-Johnsen
Oct 30, 2004·Scandinavian Journal of Public Health·Peter BjerregaardSven O E Ebbesson
May 15, 2003·Scandinavian Journal of Public Health·Peter BjerregaardGert Mulvad
Aug 11, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J WangR A Hegele
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Nov 5, 2003·International Journal of Circumpolar Health·Nancy K McGrath-HannaAbel Bult-Ito
Jul 30, 2005·International Journal of Circumpolar Health·Barbara V HowardDavid C Robbins
Feb 18, 2004·International Journal of Circumpolar Health·T Kue Young
Aug 3, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Stella AslibekyanHemant K Tiwari
Sep 15, 1998·Nutrition Reviews·S J Whiting, M L Mackenzie
Feb 16, 2008·International Journal of Circumpolar Health·Piya LahiryRobert A Hegele
Jul 3, 1999·Nutrition Reviews·R A Hegele
May 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C Milochevitch, A Khalil

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.