Are capillary DBS applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept

Bioanalysis
Lisbeth PatteetHugo Neels

Abstract

DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory. A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the blood:serum ratio. Calculation of DBS:blood ratios and Passing-Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6-97.6%). This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.

References

Feb 28, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M BernaS Glass
Jul 10, 2003·British Journal of Clinical Pharmacology·R J FlanaganT R E Barnes
Jun 6, 2007·Archives of General Psychiatry·Richard S E KeefeUNKNOWN Neurocognitive Working Group
Apr 8, 2009·Therapeutic Drug Monitoring·Peter M EdelbroekLeo M L Stolk
Apr 13, 2010·The AAPS Journal·Malcolm Rowland, Gary T Emmons
Jul 21, 2010·British Journal of Clinical Pharmacology·Baba S MohammedJames S McLay
Sep 4, 2010·Journal of Clinical Psychopharmacology·Eduard VietaBjörn Paulsson
Nov 19, 2010·Bioanalysis·Gary Emmons, Malcom Rowland
Mar 29, 2011·Forensic Science International : Synergy·Eva SaarJochen Beyer
Feb 22, 2012·Critical Reviews in Toxicology·Christophe P StoveWilly E Lambert
Sep 6, 2012·Bioanalysis·Qin C JiMark E Arnold
Nov 15, 2012·Therapeutic Drug Monitoring·Lisbeth PatteetHugo Neels
Jan 22, 2013·Journal of Pharmaceutical and Biomedical Analysis·David TemesiSamuel Dick
Mar 13, 2013·Forensic Science International : Synergy·Danielle S FisherRobert J Flanagan
Apr 11, 2013·Forensic Science International : Synergy·Danielle S FisherRobert J Flanagan
May 15, 2013·Therapeutic Drug Monitoring·Danielle S FisherRobert J Flanagan
Aug 14, 2013·Bioanalysis·Pieter Mm De KeselChristophe P Stove
Jul 2, 2014·Clinical Pharmacokinetics·Pieter M M De KeselChristophe P Stove
Sep 11, 2014·Clinical Pharmacokinetics·Abraham J WilhelmEleonora L Swart

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Citations

Oct 5, 2016·Journal of Pharmaceutical and Biomedical Analysis·Nele SadonesChristophe P Stove
Jan 29, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lisa C MartialAlbert Batalla
Mar 6, 2018·Therapeutic Drug Monitoring·Sanne M KloosterboerBirgit C P Koch
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matteo MorettiLuca Morini
Nov 18, 2018·Therapeutic Drug Monitoring·Sanne M KloosterboerBirgit C P Koch

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