Are children born after infertility treatment at increased risk of retinoblastoma?

Human Reproduction
L Foix-L'HéliasM Kaminski

Abstract

Retinoblastoma (RB) is the most frequent eye tumour in children, with an incidence of 1 in 15-20,000 births. It accounts for 11% of all cancers in the first year of life. Except for the hereditary forms, its causes are not well-known. Studies have recently suggested an increased risk of RB among children born after IVF, but the relevant literature is sparse. We assessed the association between infertility treatment, subfertility and RB. We included all children living in France diagnosed with RB between 1 January 2000 and 31 December 2006 at the Institut Curie, the national reference centre for RB diagnosis and treatment. We used multiple logistic regression to compare them with a national sample of births in France in 1998 and 2003 (n = 28 170). The study included 244 non-familial RB cases. The risk of RB increased with maternal age [adjusted odds ratio (adj OR) = 2.07, 95% confidence interval (CI) 1.33-3.22 at 35-39 years compared with younger than 25 years and adj OR = 2.42, 95% CI 1.22-4.81 at 40 years or older], but the associations with IVF (adj OR = 1.37, 95% CI 0.64-2.95) and ovarian stimulation or intrauterine insemination (adj OR = 1.35, 95% CI 0.77-2.38) were not statistically significant after adjustment for materna...Continue Reading

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Citations

Nov 28, 2013·The Lancet Oncology·Daniel OrbachFrançois Doz
May 6, 2014·Seminars in Fetal & Neonatal Medicine·Bengt Källén
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Dec 15, 2018·International Journal of Cancer. Journal International Du Cancer·Tingting WangJiabi Qin
May 22, 2021·American Journal of Epidemiology·Sarah HjorthHedvig Nordeng

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